Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

NOS knockouts and neuroprotection

Nature Medicine volume 5, pages 1354–1355 (1999)Cite this article

Abstract

Neuronal nitric oxide synthase (nNOS) is known to be involved in the dopaminergic neurodegeneration that occurs in the MPTP model of Parkinson disease. Recent studies indicate that different isoforms of NOS may act synergistically to cause neuronal injury in Parkinson disease and other neurodegenerative diseases (1403–1409).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Putative contribution of iNOS and nNOS to cell death in the MPTP model of Parkinson's disease.

References

  1. Cramer, K.S., Leamey, C.A. & Sur, M. Nitric oxide as a signaling molecule in visual system development. Prog. Brain Res. 118, 101– 114 (1998).

    Article  CAS  Google Scholar 

  2. Iadecola, C. Bright and dark sides of nitric oxide in ischemic brain injury. Trends. Neurosci. 20, 132–139 (1997).

    Article  CAS  Google Scholar 

  3. Langston, J.W., Ballard, P., Tetrud, J.W. & Irwin, I. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219, 979–980 (1983).

    Article  CAS  Google Scholar 

  4. Mandir, A.S. et al. Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. Proc. Natl. Acad. Sci. USA 96, 5774–5779 (1999).

    Article  CAS  Google Scholar 

  5. Hantraye, P. et al. Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nature. Med. 2, 1017–1021 (1996).

    Article  CAS  Google Scholar 

  6. Matthews, R.T. et al. MPP+ induced substantia nigra degeneration is attenuated in nNOS knockout mice. Neurobiol. Dis. 4, 114 –121 (1997).

    Article  CAS  Google Scholar 

  7. Iadecola, C., et al. Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia. Stroke 27, 1373–1380 (1996).

    Article  CAS  Google Scholar 

  8. Langston, J.W. et al. Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann. Neurol. 46, 598–605 (1999).

    Article  CAS  Google Scholar 

  9. Hirsch, E.C., Hunot, S., Damier, P. & Faucheux, B. Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration? Ann. Neurol. 44, S115–S120 (1998).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology New York Presbyterian Hospital Cornell University, 525 East 68th Street, New York City, 10021, New York, USA

    Thomas Grünewald & M. Flint Beal

Authors
  1. Thomas Grünewald
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Flint Beal
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Grünewald, T., Beal, M. NOS knockouts and neuroprotection. Nat Med 5, 1354–1355 (1999). https://doi.org/10.1038/70918

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/70918

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing