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Letters to Editor
Nature Medicine 5, 1330 (1999)
doi:10.1038/70877
Cell membrane estrogen receptors resurface
Richard J. Pietras1 & Clara M. Szego2
- UCLA School of Medicine, Department of Medicine-Hematology/Oncology Los Angeles, California 90095-1678, USA
- University of California Department of Molecular, Cell & Developmental Biology Los Angeles, California 90095-1606, USA
To the editor—In their recent and informative News and Views "Estrogen hits the surface," Collins and Webb1 suggested that "newly discovered estrogen receptor-dependent signaling pathways demonstrate that estrogen functions in the cytosol as well as in the nucleus." Although we agree wholeheartedly with the data cited, we regret that the authors failed to acknowledge that cell surface forms of estrogen receptors coupled to intracellular signaling pathways were first reported more than 20 years ago2, 3, 4.
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