 | About the cover
December 1999 - Vol 5 No 12
Nature Medicine 5 (1999)
| | |  | Vascular endothelial growth factor (VEGF) is essential for the development and differentiation of the vascular system. Inactivation of a single VEGF allele in mice causes embryonic
lethality at embryonic day 11, due to the lack of blood vessel development by the yolk sac. The cover photograph compares the differences in vasculature between yolk sacs from VEGF+/+ (left) and VEGF+/- embryos. In a review article on page 1359, Napoleone Ferrara and Kari Alitalo discuss the clinical applications of VEGF and other angiogenic growth factors.
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