Nature Medicine
5, 1356 - 1357 (1999)
doi:10.1038/70920
Runt domains take the lead in hematopoiesis and osteogenesisMilton H. Werner1, Katsuya Shigesada2
& Yoshiaki Ito21
Laboratory of Molecular Biophysics The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
mwerner@portugal.rockefeller.edu
2
Departments of Viral Oncology, Genetics and Molecular Biology, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606, Japan
It has been nearly a decade since AML1 was first identified as the DNA-binding protein PEBP2 B/CBFA2 in mice. Molecular, genetic and biochemical studies have converged to reveal new information about how this unique family of transcription factors functions, and the linkage between developmental processes and human disease.
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