Nature Medicine
5, 1216 (1999)
doi:10.1038/15145
Tumor invasion: molecular shears blunted by green teaSpiridione Garbisa1, Susan Biggin2, Nadia Cavallarin1, Luigi Sartor1, Roberto Benelli3
& Adriana Albini41
Institute of Histology and Embryology, Medical School
35121 Padova, Italy
garbisa@civ.bio.unipd.it
2
UNIDO-ICS AREA Science Park
34012 Trieste, Italy
3
Tumor Progression Section National Institute for Research
on Cancer IST, c/o CBA Genova, Italy
4
Molecular Biology Laboratory National Institute for
Research on Cancer IST, c/o CBA Genova, Italy
To the editor−The recent press, both popular and scientific,
has given wide coverage of the beneficial properties of green tea, most commonly
used in Asian countries. Consumption has been associated with prevention of
cancer development and metastasis1. The main flavonol of green
tea, epigallocatechin-3-gallate (EGCG), inhibits urokinase2,
one of the hydrolases implicated in tumor invasion. Moreover, green tea consumption
by mice significantly limits angiogenesis3, crucial for the
growth of all solid tumors.
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