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Volume 4 Issue 8, August 1998

Editorial

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Letters to the Editor

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News

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Commentary

  • The Office of AIDS Research, a relatively small but Influential unit within the US National Institutes of Health, is responsible for “coordinating the scientific, budgetary, legislative, and policy elements of the NIH AIDS research program”. Here the new director, Neal Nathanson, presents his vision of how the nations $1 .7 billion AIDS research effort should be used to respond to the challenge of AIDS

    • Neal Nathanson
    Commentary
  • The self-organization of cells into complex interacting systems can be described using a branch of mathematics called nonlinear dynamics, which includes the study of chaos. Here, Donald Coffey explains how analysis of complex biological systems using nonlinear dynamics sheds light on the events leading to disorders as varied as epilepsy, heart disease and cancer

    • Donald S. Coffey
    Commentary
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News & Views

  • Studying the mechanisms by which pathogens evade the immune response may lead to new therapeutic strategies (pages 939–944).

    • Stephen H. Powis
    News & Views
  • New findings apparently refute Hering's Law which holds that the eye movements of primates are yoked—that is, the two eyes are controlled as if they are one. On closer inspection they may prove to be compatible with it.

    • Lawrence Mays
    News & Views
  • Spirochetes alter their major surface proteins in response to the temperature change that accompanies their passage from tick vector to mammalian host.

    • Alan G. Barbour
    News & Views
  • A twin study suggests that different genetic and nongenetic factors operate in the development of typical versus atypical vocabulary skills.

    • Jeffrey W. Gilger
    News & Views
  • An organelle in apicomplexan parasites including those causing malaria and toxoplasmosis may be the site of a plant biosynthetic pathway that could provide new targets for drug discovery and development.

    • Robert G. Ridley
    News & Views
  • A test that identifies animal models in which fetal neural tube defects can be prevented by folic acid may shed light on how this vitamin mediates its preventive effects.

    • John M. Scott
    News & Views
  • The hematopoietic microenvironment influences gene expression in both early embryos and adults suggesting possibilities for novel transplantation therapy.

    • Saul J. Sharkis
    News & Views
  • New findings implicate apoptosis in the death of neurons in Alzheimer disease but the evidence is still insufficient to formally indict apoptosis in the neurodegeneration associated with this disease (pages 957–962).

    • George Perry
    • Akihiko Nunomura
    • Mark A. Smith
    News & Views
  • Two new mouse models closely mimic human atherosclerosis, providing exciting opportunities for elucidating the molecular mechanisms of this disease and for evaluating novel therapeutics (pages 934–938).

    • Daniel J. Rader
    • Garret A. FitzGerald
    News & Views
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Review Article

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Article

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Book Review

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Erratum

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On the Market

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