Nature Medicine
4, 899 - 900 (1998)
doi:10.1038/nm0898-899
State of the art: Atherosclerosis in a limited editionDaniel J. Rader
& Garret A. FitzGeraldCenter for Experimental Therapeutics and Departments of Pharmacology and Medicine, University of Pennsylvania Health System Philadelphia, Pennsylvania 19104, USA Two new mouse models closely mimic human atherosclerosis, providing exciting opportunities for elucidating the molecular mechanisms of this disease and for evaluating novel therapeutics (pages 934−938).
REFERENCES
- Hennekens, C.H. Increasing burden of cardiovascular disease: Current knowledge and future directions for research on risk factors. Circulation 97, 1095−1102 (1998). | PubMed | ISI | ChemPort |
- Gould, L.A., Rossouw, J.E., Santanello, N.C., Heyse, J.F. & Furberg, C.D. Cholesterol reduction yields clinical benefit: Impact of statin trials. Circulation 97, 946−952 (1998). | PubMed | ISI | ChemPort |
- Powell-Braxton, L.M. et al. A mouse model of human familial hypercholesterolemia: Markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat, chow diet. Nature Med. 4, 934−938 (1998). | Article | PubMed | ISI | ChemPort |
- Sanan, D.A. et al. Low density lipoprotein receptor-negative mice expressing human apolipoprotein B-100 develop complex atherosclerotic lesions on a chow diet: No accentuation by apolipoprotein (a). Proc. Natl. Acad. Sci. USA 95, 4544−4549 (1998). | Article | PubMed | ChemPort |
- Paigen, B., Morrow, A., Holmes, P.A., Mitchell, D. & William, R.A. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis 68, 231−240 (1987). | PubMed | ISI | ChemPort |
- Breslow, J.L. Mouse models of atherosclerosis. Science 272, 685−688 (1996). | PubMed | ISI | ChemPort |
- Plump, A.S. et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 71, 343−353 (1992). | Article | PubMed | ISI | ChemPort |
- Zhang, S., Reddick, R., Piedrahita, J. & Maeda, N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 258, 468−471 (1992). | PubMed | ISI | ChemPort |
- Nakashima, Y., Plump, A.S., Raines, E.W., Breslow, J.L. & Ross, R. ApoE-deficient mice develop lesions in all phases of atherosclerosis throughout the arterial tree. Arteriosclerosis and Thrombosis 14, 133−140 (1994). | PubMed | ISI | ChemPort |
- Ishibashi, S., Goldstein, J., Brown, M., Herz, J. & Burns, D. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice. J. Clin. Invest. 93, 1885−1893 (1994). | PubMed | ISI | ChemPort |
- Tangirala, R.K., Rubin, E.M. & Palinski, W. Quantitation of atherosclerosis in murine models: Correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between the sexes in LDL receptor-deficient and apolipoprotein E-deficient mice. J. Lipid Res. 36, 2320−2328 (1995). | PubMed | ISI | ChemPort |
- Davidson, N.O., Anant, S. & MacGinnitie, A.J. Apolipoprotein B messenger RNA editing: Insights into the molecular regulation of post-transcrip-tional cytidine deamination. Curr Opin Lipidol 6, 70−74 (1995). | PubMed | ChemPort |
- Rohlmann, A., Gotthardt, M., Hammer, R.E. & Herz, J. Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. J. Clin. Invest. 101, 689−695 (1998). | PubMed | ISI | ChemPort |
- Hirano, K. et al. Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B-48. Biol Chem. 271, 9887−9890 (1996). | Article | ChemPort |
- Farese, R.V. et al. Phenotypic analysis of mice expressing exclusively apolipoprotein B-48 or apolipoprotein B-100. Proc. Natl. Acad. Sci. USA 93, 6393−6398 (1996). | Article | PubMed | ChemPort |
- Kim, E. & Young, S.G. Genetically modified mice for the study of apolipoprotein B. J. Lipid Res. 39, 703−723 (1998). | PubMed | ISI | ChemPort |
|
