Nature Medicine
4, 768 - 769 (1998)
doi:10.1038/nm0798-768
Brain injury and immunosuppressionCarlos R. Plata-SalamánDivision of Molecular Biology, School of Life and Health Sciences, University of Delaware, Newark, Delaware 19716-2590, USA e-mail: crps@udel.edu Catecholamine-induced release of the immunosuppressive cytokine IL-10 is associated with an increase in infection and sepsis among patients with acute brain injury (803−813). REFERENCES
- Woiciechowsky, C. et al. Mechanism of brain injury-induced immunodepression: Sympathetic activation triggers systemic interleukin-10 release. Nature Med. 4, 808−813 (1998). | Article | PubMed | ISI | ChemPort |
- de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C.G. & de Vries, J.E. Interleukin-10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174, 1209−1220 (1991). | Article | PubMed | ChemPort |
- Fuchs, A. C. et al. Clinical, hematologic and immunologic effects of interleukin-10 in humans. J. Clin. Immunol. 61, 291−303 (1996).
- Elenkov, I.J., Papanicolaou, D.A., Wilter, R.L.&Chrousos, G.P. Modulatory effects of glococorticoids and catecholamines on human interleukin-12 and interleukin-10 production: clinical implications. Proc. Assoc: Am. Physicians 108, 374−381 (1996). | PubMed | ISI | ChemPort |
- van der Poll, T., Coyle, S. M., Barbosa, K., Braxton, C. C. St Lowry, S.F. Epinephrine inhibits tumor necrosis factor a and potentiates interleukin-10 production during human endotoxemia. J. Clin. Invest. 97, 713−719 (1996). | PubMed | ChemPort |
- Plata-Salaman, C. R., & llyin, S. E. IL-1
-induced modulation of the hypothalamic IL-1 system, TNF- and TGF- 1 mRNAs in obese (fa/fa) and lean (Fa/Fa) Zucker rats: Implications for IL-1 p feedback systems and cytokine-cytokine interactions. J. Neurosci. Res. 49, 541−550 (1997). | Article | PubMed | ChemPort |
- Morganti-Kossmann, M. C. et al. Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue. Mol. Psychiatry 2, 133−136 (1997). | Article | PubMed |
- Bell, M. J. et al. lnterleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children. J. Neurotrauma 14, 451−457 (1997). | PubMed |
- Woiciechowsky, C. et al. Different release of cytokines into the cerebrospinal fluid following surgery for intra- and extra-axial brain tumours. Acta Neurochir. Wien. 139, 619−624 (1997). | PubMed | ChemPort |
- Suberville, S. et al. Regulation of interleukin-10 production by
-adrenergic agonists. Eur. J. Immunol. 26, 2601−2605 (1996). | PubMed | ISI | ChemPort |
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