Nature Medicine
4, 669 - 670 (1998)
doi:10.1038/nm0698-669
Neuronal grafts for Huntington's diseasePhilippe Horellou
& Jacques MalletLaboratoire de Génétique Moléculaire de la, Neurotransmission et des Processus Dégénératifs Hôpital de la Pitié Salpêtrière, 75013 Paris, France Embryonic striatal neurons transplanted into marmoset brains become integrated into host tissue and induce functional recovery in a primate model of Huntington's disease (pages 727−729).
REFERENCES
- Kendall, A.L. et al. Functional integration of striatal allografts in a primate model of Huntington's disease. Nature Med. 4, 727−729 (1998). | Article | PubMed | ISI | ChemPort |
- Huntington's Disease Collaborative Research Group A novel gene containing a trinucleotide repeat that is unstable in Huntington's disease chromosomes. Cell 72, 971−983 (1993). | PubMed | ISI |
- Duyao, M. et al. Trinucleotide repeat length instability and age of onset in Huntington's disease. Nature Genet. 4, 387−392 (1993). | PubMed | ISI | ChemPort |
- Andrew, S.E. et al. The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease. Nature Genet. 4, 398−403 (1993). | PubMed | ISI | ChemPort |
- MacDonald, M.E. & Gusella, J.F. Huntington's disease: Translating a CAG repeat into a pathogenic mechanism. Curr. Opin. Neurobiol. 6, 638−643 (1996). | Article | PubMed | ISI | ChemPort |
- Strong, T.V. et al. Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues. Nature Genet. 5, 259−265 (1993). | PubMed | ISI | ChemPort |
- Ferrante, R.J. et al. Heterogeneous topographic and cellular distribution of huntingtin expression in the normal human neostriatum. J. Neurosci. 9, 3052−3063 (1997).
- Mangiarini, L. et al. Exon 1 of the Huntington's disease gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87, 493−506 (1996). | Article | PubMed | ISI | ChemPort |
- Davies, S.W. et al. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 90, 537−548 (1997). | Article | PubMed | ISI | ChemPort |
- DiFiglia, M. et al. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277, 1990−1993 (1997). | Article | PubMed | ISI | ChemPort |
- Björklund, A. & Stenevi, U. Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants. Brain Res. 177, 555−560 (1979). | Article | PubMed | ISI |
- Lindvall, O. et al. Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's disease. Science, 247, 574−577 (1990). | PubMed | ISI | ChemPort |
- Dunnett, S.B. & Svendsen, C.N. Huntington's disease: animal models and transplantation repair. Curr. Opin. Neurobiol. 3, 790−796 (1993). | Article | PubMed | ChemPort |
- Nakao, N., Grasbon-Frodl, E.M., Widner, H. & Brundin, P. DARPP-32-rich zones in grafts of lateral ganglionic eminence govern the extent of functional recovery in skilled paw reaching in an animal model of Huntington's disease. Neuroscience 74, 959−970 (1996) | PubMed | ISI | ChemPort |
- Kopyov, O.V., Jacques, S., Lieberman, A., Duma, C.M. & Eagle, K.S. Safety of intrastriatal neurotransplantation for Huntington's disease patients. Exp. Neurol. 149, 97−108 (1998). | Article | PubMed | ISI | ChemPort |
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