Nature Medicine
4, 661 - 662 (1998)
doi:10.1038/nm0698-661
Calcineurin—the missing link in cardiac hypertrophySeigo Izumo
& Hiroki AokiCardiovascular Division, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA e-mail: sizumo@bidmc.harvard.edu Transgenic mice that overexpress calcineurin develop cardiac hypertrophy, which can be prevented by treatment with immunosuppressive drugs that inhibit calcineurin.
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