Nature Medicine
4, 659 - 660 (1998)
doi:10.1038/nm0698-659
Nicotine addiction and the lure of rewardFrancis J. WhiteDepartment of Cellular and Molecular Pharmacology, Finch University of Health Sciences/The Chicago Medical School, North Chicago, Illinois 60064-3095, USA email: whitef@mis.finchcms.edu Withdrawal from chronic nicotine exposure decreases the activity of the brain reward pathway in a manner similar to other addictive drugs.
REFERENCES
- Epping-Jordan, M.P., Watkins, S.S., Koob, G. & Markou, A. Dramatic decreases in brain reward function during nicotine withdrawal. Nature 393, 76−79 (1998). | Article | PubMed | ISI | ChemPort |
- Olds, J. & Milner, P. Positive reinforcement produced by electrical stimulation of septal area and other regions of the brain. J. Comp. Physiol. Psychol. 47, 419−427 (1954). | PubMed | ISI | ChemPort |
- Wise, R.A. Addictive drugs and brain stimulation reward. Annu. Rev. Neurosci. 19, 319−340 (1996). | Article | PubMed | ISI | ChemPort |
- Markou, A. & Koob, G.F. Postcocaine anhedonia: an animal model of cocaine withdrawal. Neuropsychopharmacology 4, 17−26 (1991). | PubMed | ISI | ChemPort |
- Robinson, T.E. & Berridge, K.C. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res. Rev. 18, 247−291 (1993). | Article | PubMed | ISI | ChemPort |
- Wise, R.A. & Bozarth, M.A. A psychomotor stimulant theory of addiction. Psychol. Rev. 94, 469−492 (1987). | Article | PubMed | ISI | ChemPort |
- Self, D.W. & Nestler, E.J. Molecular mechanisms of drug reinforcement and addiction. Annu. Rev. Neurosci. 18, 463−495 (1995). | Article | PubMed | ISI | ChemPort |
- Corrigall, W.A., Franklin, K.B., Coen, K.M. & Clarke, P.B.S. The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine. Psychopharmacology 107, 285−289 (1992). | PubMed | ISI | ChemPort |
- Wonnacott, S. Presynaptic nicotinic ACh receptors. Trends Neurosci. 20, 92−98 (1997). | Article | PubMed | ISI | ChemPort |
- Marks, M.J., Burch, J.B. & Collins, A.C. Effects of chronic nicotine infusion on tolerance development and cholinergic receptors. J. Pharmacol. Exp. Ther. 226, 806−816 (1983). | PubMed |
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