The next frontier of molecular medicine: Delivery of therapeutics
Rakesh K. Jain
Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA http://steele.mgh.harvard.edu
Despite exciting progress in the biology underlying a variety of proposed molecular medicines, an unmet challenge
Remains—delivery. This problem, how to better target the new generation of therapeutics, cuts across all diseases. The
solution offers unprecedented opportunities for multidisciplinary teams of bioengineers to work with biological and
medical scientists to realize the fruits of our nation's investment in molecular and cellular medicine.
REFERENCES
Jain, R.K. Delivery of Molecular Medicine to Solid Tumors. Science271, 1079−1080 (1996). | PubMed | ISI | ChemPort |
Klausner, R.D., The Nation's Investment in Cancer Research: A Budget Proposal for Fiscal Year 1999. National Cancer Institute (September 1997).
Jain, R.K. 1996 Eugene M. Landis Award Lecture: Delivery of Molecular and Cellular Medicine to Solid Tumors. Microcirculation4, 1−23 (1997). | PubMed | ChemPort |
Jain, R.K., Schlenger, K., Höckel, M. & Yuan, F. Quantitative Angiofenesis Assays: Progress and Problems. Nature Med.3, 1203−1208 (1997). | PubMed | ISI | ChemPort |
Fidler, I.J. Modulation of the organ microenvironment for treatment of cancer metastasis. J. Natl. Cancer Inst.87, 1588−1592 (1995). | PubMed | ChemPort |
Hanahan, D. & Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell6, 353−64 (1996).
Kerbel, R.S. A cancer therapy resistant to resistance. Nature390, 335−336 (1997). | Article | PubMed | ISI | ChemPort |
Arap, W., Pasqualini, R. & Ruoslahti, E. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science279, 377−380 (1998). | Article | PubMed | ISI | ChemPort |
Baxter, L.T., Zhu, H., Butler, W.F., Mackensen, D.G. & Jain, R.K. Biodistribution of monoclonal antibodies: scale-up from mouse to man using a physiologically-based pharmacokinetic model. Cancer Res.55, 4611−4622 (1995). | PubMed | ISI | ChemPort |
