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Nature Medicine  4, 559 - 560 (1998)
doi:10.1038/nm0598-559

Glimpsing the cause of rhabdomyosarcoma

Shili Zhan & Lee J. Helman

Pediatric Oncology Branch, National Cancer Institute, 10 Center Drive, Building 10, Room 13N240, Bethesda, Maryland 20892-1928, USA. Email: helmanl@pbmac.nci.nih.gov

A mouse model of Gorlin's syndrome implicates mutations in patched and upregulation of insulin growth factor 2 in the etiology of rhabdomyosarcoma (pages 619−622).

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  2. Münsterberg, A.E., Kitajewski, J., Bumcrot, D.A., McMahon, A.P. & Lassar, A.B. Combinatorial signaling by sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. Genes Dev. 9, 2911−2922 (1995). | PubMed  | ISI |
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  7. Gailani, M.R. et al. The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas. Nature Genet. 13, 78−81 (1996) | PubMed  |
  8. Hahn, H. et al. Mutations in the human homologue of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85, 841−851 (1996). | Article | PubMed  | ISI | ChemPort |
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  10. Goodrich, L.V., Milenkovic, L., Higgins, K.M. & Scott, M.P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277, 1109−1113 (1997). | Article | PubMed  | ISI | ChemPort |
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  13. Minniti, C.P., Tsokos, M., Newton, Jr., W.A. & Helman, L.J. Specific expression of insulin-like growth factor-II in rhabdomyosarcoma tumor cells. Am. J. Clin. Path. 101, 198−203 (1994). | PubMed  | ISI | ChemPort |
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ISSN: 1078-8956
EISSN: 1546-170X
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