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Nature Medicine  4, 395 - 396 (1998)
doi:10.1038/nm0498-395

Death to a blood vessel, death to a tumor

David A. Cheresh

Departments of Immunology and Vascular Biology The Scripps Research Institute La Jolla, California 92037, USA email: cheresh@scripps.edu

Suppression of endothelial cell alphaVbeta3 activity by TNF and IFN-bold gamma disrupts angiogenesis and promotes the demise of malignant melanoma (pages 408−414).

REFERENCES
  1. Brooks, P.C., Clark, R.A.F. & Cheresh, D.A. Requirement of vascular integrin aV$3 for angiogenesis. Science 264, 569−571 (1994). | PubMed  | ISI | ChemPort |
  2. Ruegg, C. et al. Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma. Nature Med. 4, 408−414 (1998). | Article | PubMed  | ISI | ChemPort |
  3. Brooks, P.C. et al. Integrin alphaVbeta3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79, 1157−1164 (1994). | Article | PubMed  | ISI | ChemPort |
  4. Friedlander, M. et al. Definition of two angiogenic pathways by distinct alphaVbeta33 integrins. Science 270, 1500−1502 (1995). | PubMed  | ISI | ChemPort |
  5. Stromblad, S., Becker, J.C., Yebra, M., Brooks, P.C. & Cheresh, D.A. Suppression of p53 and p21 expression by vascular cell integrin alphaVbeta3 during angiogenesis in vivo. J. Clin. Invest. 98, 426−433 (1996). | PubMed  | ISI | ChemPort |
  6. Gutheil, J.C. et al. Phase I study of Vitaxin, an anti-angiogenic humanized monoclonal antibody to vascular integrin alphaVbeta3, Proc. Am. Soc. Clin. Oncol. (in the press).
  7. Yuan, F. et al. Time dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor antibody. Proc. Natl. Acad. Sci, USA 93, 14765−14770 (1996). | Article | PubMed  | ChemPort |
  8. Elicieri, B.P., Klemke, R., Stromblad, S. & Cheresh, D.A. Integrin alphaVbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis. J. Cell Biol. (in the press).
  9. Campbell, J.J. et al. Biology of cherrtokine and classical chemoattractant receptors: Differential requirements for adhesion triggering versus chemotactic responses in lymphoid cells. J. Cell Biol. 134, 255−266 (1996). | Article | PubMed  | ISI | ChemPort |
  10. Vassboth, F.S. et al. Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha receptor. J. Biol. Chem. 269, 13874−13879 (1994). | PubMed  |
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ISSN: 1078-8956
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