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Nature Medicine  4, 394 - 395 (1998)
doi:10.1038/nm0498-394

Monster plaques: What they tell us about Alzheimer's disease

Bruce A. Yankner

Division of Neuroscience The Children's Hospital and Department of Neurology Harvard Medical School Boston, Massachusetts 02115, USA

An unusual variant of Alzheimer's disease challenges the role of classic amyloid plaques in the pathogenesis of dementia (pages 452−455).

REFERENCES
  1. Sherrington, R. et al. Cloning of a gene bearing mis-sense mutations in early-onset familial Alzheimer's disease. Nature 375, 754−760 (1995). | Article | PubMed  | ISI | ChemPort |
  2. Levy-Lahad, E. et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269,973−977(1995). | PubMed  | ChemPort |
  3. Kwok, J.B. et al. Two novel (M233T and R278T) pre-senilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype. Neuroreport 8, 1537−1542 (1997). | PubMed  | ISI | ChemPort |
  4. Crook, R. et al. A variant of Alzheimer's disease with spastic paraparesis and 'cotton wool' plaques due to deletion of exon 9 of presenilin 1. Nature Med. 4, 452−455 (1998). | Article | PubMed  | ISI | ChemPort |
  5. Suzuki, N. et al. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (betaAPP717) mutants. Science 264, 1336−1340(1994). | PubMed  | ISI | ChemPort |
  6. Scheuner, D. et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin-1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 2,864−870 (1996). | PubMed  | ISI | ChemPort |
  7. Duff, K. et al. Increased amyloid-beta42(43) in brains of mice expressing presenilin 1. Nature 383, 710−713 (1996). | Article | PubMed  | ISI | ChemPort |
  8. Borchelt, D.R. et al. Familial Alzheimer's disease-linked presenilin-1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 17, 1005−1013 (1996). | Article | PubMed  | ISI | ChemPort |
  9. Citron, M. et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nature Med. 3, 67−72 (1997). | PubMed  | ISI | ChemPort |
  10. Jarrett, J.T. & Lansbury, P.T. Seeding 'one-dimensional crystallization' of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie? Cell 73,1055−1058(1993). | PubMed  | ISI | ChemPort |
  11. Yankner, B.A. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16, 921−932 (1996). | Article | PubMed  | ISI | ChemPort |
  12. Pike, C.J., Burdick, D., Walencewicz, A.J., Glabe, C.G. & Cotman, C. Neurodegeneration induced by beta-amyloid peptides in vitro: The role of peptide assembly state. J. Neurosci. 13,1676−1687 (1993). | PubMed  | ISI | ChemPort |
  13. Mattson, M.P., Tomaselli, K.J. & Rydel, R.E. Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FCF. Brain Res. 621,35−49 (1993). | Article | PubMed  | ISI | ChemPort |
  14. Lorenzo, A. & Yankner, B.A. Beta-amyloid neurotoxi-city requires fibril formation and is inhibited by Congo Red. Proc. Natl. Acad. Sci. USA 91, 12243−12247(1994). | PubMed  | ChemPort |
  15. Nochlin, D., Bird, T.D., Nemens, E.J., Ball, M.J & Sumi, S.M. Amyloid angiopathy in a Volga German family with Alzheimer's disease and a presenilin-2 mutation (N141). Ann. Neurol. 43, 131−135 (1998). | PubMed  | ISI | ChemPort |
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