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Nature Medicine  4, 392 - 393 (1998)
doi:10.1038/nm0498-392

COX-2 inhibitors for colorectal cancer

Douglas J. E. Elder & Christos Paraskeva

Department of Pathology and Microbiology University of Bristol Bristol, BS8 1TD, UK C.Paraskeva@bristol.ac.uk

COX-2 selective non-steroidal anti-inflammatory drugs show promise in the prevention of coiorectal cancer and possibly other tumors.

REFERENCES
  1. Shift, S.J. & Rigas, B. Nonsteroidal antiinflamma-tory drugs and colorectal cancer: evolving concepts of their chemopreventive actions. Gastroenterology 113 1992−1998 (1997). | PubMed  | ISI | ChemPort |
  2. Kawamori, T., Rao, C.V., Seibert, K. & Reddy, B.S. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis. Cancer Res. 58, 409−412 (1998). | PubMed  | ISI | ChemPort |
  3. Williams, C.S. & DuBois, R.N. Prostaglandin endoperoxide synthase: Why two isoforms? Am. J. Physiol 270, G393−G400 (1996). | PubMed  | ISI | ChemPort |
  4. Oshima, M. et al. Suppression of intestinal polyposis in ApcDelta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87, 803−809 (1996). | Article | PubMed  | ISI | ChemPort |
  5. Sheng, H., Shao, J., Morrow, J.D., Beauchamp, R.D. & DuBois, R.N. Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res. 58, 362−366 (1998). | PubMed  | ISI | ChemPort |
  6. Chan, T.A., Morin, P.J., Vogelstein, B. & Kinzler, K.W. Mechanisms underlying nonsteroidal anti-inflammatory drug-mediated apoptosis. Proc. Natl. Acad. Sci. USA 95, 681−686 (1998). | Article | PubMed  | ChemPort |
  7. Piazza, G.A. et al. Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels. Cancer Res. 57, 2909−2915 (1997). | PubMed  | ISI | ChemPort |
  8. Elder, D.J.E., Halton, D.E., Hague, A. & Paraskeva, C. Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression. Clin. Can. Res. 3, 1679−1683 (1997). | ISI | ChemPort |
  9. Vane, J. Towards a better aspirin. Nature 367, 215−216 (1994). | Article | PubMed  | ISI | ChemPort |
  10. Hong, S.H. et al. Regulation of head and neck tumor cell growth with cyclooxygenase-2 specific inhibitor, ketorolac. Cancer Res. 39, 196 (1998).
  11. Hwang, D. et al. Expression of cyclooxygenase in human breast cancer. Cancer Res. 39, 353 (1998).
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