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Nature Medicine  4, 386 - 388 (1998)
doi:10.1038/nm0498-386

Microchimerism: Friend or foe?

Alan Tyndall1 & Alois Gratwohl2

  1Department of Rheumatology, University of Basel CH-4031 Basel, Switzerland

  2Division of Hematology, University of Basel CH-4031 Basel, Switzerland

Non-self fetal cells in women with scleroderma suggest a mechanism similar to allogeneic graft-versus-host disease in autoimmunity.

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  2. Artlett, C.M., Smith, J.B. & Jimenez, S.A. Identification of fetal cells in the active lesions of skin biopsies of women with systemic sclerosis. Arthritis Rheum. 40, S218 (1997).
  3. Gratwohl, A. et al. Sjogren-type syndrome after allogeneic bone marrow transplantation. Ann. Int. Med. 87, 703−706 (1977) | PubMed  |
  4. Lawley, T. et al. Scleroderma, Sjogren-type syndrome and chronic graft-versus-host disease. Ann. Int. Med. 87, 707−709 (1977). | PubMed  | ISI | ChemPort |
  5. Artlett, C.M., Welsh, K.I., Black, C.M. & Jimenez, S.A. Fetal-maternal HLA compatibilty confers susceptibility to systemic sclerosis. Immunogenetics 47, 17−22 (1 998). | PubMed  | ChemPort |
  6. Orlin, J.B. & Ellis, M.H. Transfusion associated graft-versus-host disease. Curr. Opin. Hematol. 4, 442−448 (1997) | PubMed  | ChemPort |
  7. Welsh, K.I. Scleroderma: chimerism, the blind man and the scientist. Lancet 351, 540−541 (1998). | Article | PubMed  | ISI | ChemPort |
  8. Alamas, S.P., Wigley, F.M. & White, B. Is microen-graftment with maternal or fetal cells a risk factor for the development of systemic sclerosis? Arthritis Rheum. 40, S199 (1997).
  9. Sykes, M. et al. Induction of high levels of allogeneic hematopoietic reconstitution and donor specific tolerance without myelosuppressive conditioning. Nature Med. 3, 783−787 (1997). | PubMed  | ISI | ChemPort |
  10. Tyndall, A. & Cratwohl, A. Blood and bone marrow stem cell transplants in autoimmune disease: A consensus report written on behalf of the European League Against Rheumatism (EULAR) and the European Group for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant 19, 643−645 (1997). | Article | PubMed  | ISI | ChemPort |
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ISSN: 1078-8956
EISSN: 1546-170X
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