Orexins and appetite: The big picture of energy homeostasis gets a little bigger

1. Sakurai, T. et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G-protein-coupled receptors that regulate feeding behavior. Cell 92, 573−585 (1998). | Article | PubMed  | ISI | ChemPort |
2. Schwartz, M. & Seeley, R. Neuroendocrine responses to starvation and weight loss. New Engl. J. Med. 336, 1802−1811 (1997). | Article | PubMed  | ISI | ChemPort |
3. Stephens, T.W. et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377, 530−532 (1995). | Article | PubMed  | ISI | ChemPort |
4. Schwartz, M.W. et al. Leptin increases proopiome-lanocortin (POMC) mRNA expression in the rostral arcuate nucleus. Diabetes 46, 2119−2123 (1997). | PubMed  | ISI | ChemPort |
5. Cone, R. et al. The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Progress In Hormone Research 51, 287−318 (1996). | PubMed  | ISI | ChemPort |
6. Huszar, D. et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131−141 (1997). | Article | PubMed  | ISI | ChemPort |
7. Ollmann, M. et al. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278, 135−138 (1997). | Article | PubMed  | ISI | ChemPort |
8. Seeley, R. et al. Evidence that the hypothalamic melanocortin system mediates leptin's effects on food intake and body weight. Nature 390, 349 (1997). | Article | PubMed  | ChemPort |
9. Stanley, B.G., Kyrkouli, S.E., Lampert, S. & Leibowitz, S.F. Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity. Peptides 7, 1189−1192 (1986). | Article | PubMed  | ISI | ChemPort |
10. Rossi, M. et al. Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology 138, 351−155 (1997). | Article | PubMed  | ISI | ChemPort |
11. Smith, B., York, D. & Bray, G. Chronic cerebroventricular galanin does not induce sustained hyperphagia or obesity. Peptides 15, 1267−1272 (1994). | Article | PubMed  | ISI | ChemPort |
12. Schaffhauser, A.O. et al. Inhibition of food intake by neuropeptide Y Y5 receptor antisense oligodeoxynu-cleotides. Diabetes 46, 1792−1798 (1997). | PubMed  | ISI | ChemPort |
13. Erickson, J.C., Clegg, K.E. & Palmiter, R.D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381, 415−418 (1996). | Article | PubMed  | ISI | ChemPort |
14. Connolly, H. et al. Valvular heart disease associated with fenfluramine-phentermine. New Engl. J. Med. 337, 581−588 (1997). | Article | PubMed  | ISI | ChemPort |

	Top

	Top