Nature Medicine
4, 365 - 368 (1998)
doi:10.1038/nm0398-365
Microspheres containing plasmid-encoded antigens elicit cytotoxic T-cell responsesMary Lynne Hedley1, Joanne Curley2, 3
& Robert Urban1
1Pangaea Pharmaceuticals Inc., 763E Concord Avenue, Cambridge, Massachusetts 02138, USA
2Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
3Current address: Incyte Pharmaceuticals, 1060 East Meadow Circle, Palo Alto, California 94303, USA email: mlhedley@pangaea-pharm.com
REFERENCES
- Pardoll, D. & Beckerieg, A.M. Exposing the immunology of naked DNA vaccines. Immunity 3, 165−169 (1995). | Article | PubMed | ISI | ChemPort |
- McDonnell, W.M. & Askari, F.K. DNA vaccines. New Engl. J. Med. 334, 42−45 (1996). | Article | PubMed | ISI | ChemPort |
- Corr, M., Lee, D.J., Carson, D.A. & Tighe, H. +Gene vaccination with naked plasmid DNA: Mechanism of CTL priming. J. Exp. Med. 184, 1555−1560 (1996). | Article | PubMed | ISI | ChemPort |
- Doe, B., Selby, M., Barnett, S., Baenziger, J. & Walker, C. Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow derived cells. Proc. Natl. Acad. Sci. USA 93, 8578−8583 (1996). | Article | PubMed | ChemPort |
- Iwasaki, A., Torres, C.A.T., Ohashi, P.S., Robinson, H.L. & Barber, B.H.J. The dominant role of bone marrow derived cells in CTL induction following plasmid DNA immunization at different sites. Immunology 159, 11−14 (1997). | ChemPort |
- Okada, H. & Toguchi, H. Biodegradable microspheres in drug delivery. Crit. Rev. Ther. Drug Carrier Sys. 12, 1−99 (1995). | ISI | ChemPort |
- Tabata, Y. & Ikada, Y. Phagocytosis of polymer microspheres by macrophages. Adv. Polymer Sci. 94, 107−141 (1990). | ISI | ChemPort |
- Kanke, M., Geissler, R.G., Powell, D., Kaplan, A. & DeLuca, P.P.J. Interaction of microspheres with blood constituents. III. Macrophage phagocytosis of various types of polymeric drug carriers. Parenteral Sci. Technol. 42, 157−165 (1988). | ChemPort |
- Carbone, F.R. & Bevan, M.J. Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization. J. Exp. Med. 169, 603−612 (1989). | Article | PubMed | ISI | ChemPort |
- Vitiello, A. et al. Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. J. Clin. Invest. 95, 341−349 (1995). | PubMed | ISI | ChemPort |
- Fayolle, C., et al. Induction of cytotoxic T-cell response by optimal length peptides does not require CD4+ T-cell help. Immunology 89, 41−45 (1996). | Article | PubMed | ISI | ChemPort |
- Anton, L.C., Yewdall, J.W. & Bennink, J.R. MHC-class I associated peptides produced from endogenous gene products with vastly different efficiencies. J. Immunol. 158, 2535−2542 (1997). | PubMed | ISI | ChemPort |
|
