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Nature Medicine  4, 157 - 158 (1998)
doi:10.1038/nm0298-157

Finding the failure mechanism in Sudden Infant Death Syndrome

Ronald M. Harper1 & Richard Bandler2

  1Dept. of Neurobiology and the Brain Research Institute, University of California at Los Angeles, Los Angeles, CA 90095-1763, USA

  2Dept of Anatomy and Histology and Dept. of Pain Management and Research, Royal North Shore Hospital, The University of Sydney Sydney, NSW 2006 Australia

Recent results showing decreased receptor binding in the brainstem of children with SIDS are consistent with a primary cardiovascular failure in this syndrome.

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  2. Panigrahy, A. et al. Decreased kainate receptor binding in the arcuate nucleus of the Sudden Infant Death Syndrome. J. Neuropath. Exper: Neurol. 56, 1253−1261 (1997). | ISI | ChemPort |
  3. Schechtman, V.L., Harper, R.M., Wilson, A.J. & Southall, D.P. Sleep apnea in infants who succumb to the sudden infant death syndrome. Pediatrics 87, 841−846 (1991). | PubMed  | ISI | ChemPort |
  4. Harper, R.M. Physiological mechanisms related to the Sudden Infant Death Syndrome. Sudden Infant Death Syndrome Alliance 1997 National Conference, pages 156−157 (1997).
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  6. Meny, R.G., Carroll, J.L., Carbone, M.T. & Kelly, D.H. Cardiorespiratory recordings from infants dying suddenly and unexpectedly at home. Pediatrics 93, 43−49 (1994).
  7. Southall, D.P. et al. Sinus tachycardia in infants subsequently suffering from the sudden infant death syndrome. Eur. J. Pediatr. 147, 74−78 (1988). | Article | PubMed  | ISI | ChemPort |
  8. Amemiya, F., Vos, J.E. & Prechtl, H.F.R. Effects of prone and supine position on heart rate, respiratory rate and motor activity in fullterm newborn infants. Brain Dew. 13, 148−154 (1991). | ChemPort |
  9. Zee, N., Filiano, J.J. & Kinney, H.C. Anatomic relationships of the human arcuate nucleus of the medulla: a Dil labeling study. J. Neuropathol. Exp. Neurol. 56, 509−522 (1997). | PubMed  |
  10. Henderson, L.A., Keay, K.A. & Bandler, R. The ventrolateral periaqueductal gray projects to caudal brainstem depressor regions: A functional-anatomical and physiological study. Neuroscience 82, 201−221 (1998). | Article | PubMed  | ISI | ChemPort |
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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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