Department of Medicine, University of Chicago Medical Center, Chicago, Illinois 60637, USA email: jdrowley@mcis.bsd.uchicago.edu
The finding of leukemic cells in the newborn blood of infants who developed acute leukemia in the first few years of life suggests that some leukemias are present in utero.
REFERENCES
Gale, K.B. et al. Backtracking leukemia to birth: Identification of clonotypic gene fusion sequences in neonatal blood spots. Proc. Natl. Acad. Sci. USA, 94, 13950−13954 (1997). | Article | PubMed | ChemPort |
Thirman, M.J. et al. Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. New Engl. J. Med.329, 909−914 (1993). | Article | PubMed | ISI | ChemPort |
Ford, A.M. et al. Fetal origins of the TEL−AML1 fusion gene in identical twins with leukemia. Proc. Natl. Acad. Sci. USA (in the press).
Pedersen-Bjergaard, J. & Rowley, J.D. The balanced and the unbalanced chromosome aberrations of acute myeloid leukemia may develop in different ways and may contribute differently to malignant transformation. Blood83, 2780−2786 (1994). | PubMed | ChemPort |
Strissel-Broeker, P.L. et al. Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: Correlation with scaffold attachment regions and topoisomerase II consensus binding sites. Blood87, 1912−1922 (1996). | PubMed | ISI | ChemPort |
Aplan, P.D., Chervinsky, D.S., Stanulla, M. & Burhans, W.C. Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors. Blood87, 2649−2658 (1996). | PubMed | ISI | ChemPort |
Cimino, G. et al. Infant acute leukemias show the same biased distribution of ALL1 gene breaks as topoisomerase II related secondary acute leukemias. Cancer Res.57, 2879−2883 (1997). | PubMed | ISI | ChemPort |
Ross, J.A., Potter, J.D. & Robison, L.L. Infant leukemia, topoisomerase II inhibitors, and the MLL gene. J. Natl. Cancer. Inst.86, 1678−1680 (1994). | PubMed | ChemPort |
Greaves, M.F. Infant leukaemia biology, aetiology and treatment (Workshop Report). Leukemia10, 372−377 (1996). | PubMed | ISI | ChemPort |
Uckun, F.M. et al. Expression of MLL−AF4 fusion transcripts in normal and leukemic human hematopoiesis. Blood90 (Suppl), 557a (1997).
Corral, J. et al. An MII−AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes. Cell85, 853−861 (1996). | Article | PubMed | ISI | ChemPort |
