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Nature Medicine 4, 1364 - 1365 (1998)
doi:10.1038/3947

Heme oxygenase: Protective gene or Trojan horse

Jeffrey L. Platt1 & Karl A. Nath2

  1. Departments of Surgery, Immunology, and Pediatrics Mayo Clinic, Rochester, Minnesota 55905, USA e-mail: platt.jeffrey@mayo.edu
  2. Department of Medicine Mayo Clinic, Rochester, Minnesota 55905, USA


The induction of heme oxygenase-1 in mouse cardiac allografts that do not show accelerated arteriosclerosis suggests that this enzyme may protect against the chronic rejection of transplants (pages 1392–1396).