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Nature Medicine  4, 1366 - 1367 (1998)
doi:10.1038/3949

G-quadruplex DNA: A target for drug design

Jean-Louis Mergny & Claude Hélène

Laboratoire de Biophysique Muséum National d'Histoire Naturelle INSERM U 201, CNRS UA 481 75005 Paris, France biophy@cimrs1.mnhn.fr

Compounds that stabilize G-quadruplex structures in telomeric DNA block telomerase activity and may be potentially valuable as antitumor drugs.

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