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Letters to Editor
Nature Medicine 4, 1210 - 1211 (1998)
doi:10.1038/3174
Reply to Heat shock proteins, HLA-DR and rheumatoid arthritis
Isabelle Auger1 & Jean Roudier1
- Laboratoire d'Immuno Rhumatologie, INSERM CRI 4U009D Faculté de Médecine, 13005 Marseille, France
Reply—Our Nature Medicine article1 and a follow-up article4 make two points, both challenged by Rich et al. First, the QKRAA amino-acid motif, which, when expressed on HLA-DR, helps the development of rheumatoid arthritis, is also expressed on the Escherichia coli heat shock protein DnaJ and helps DnaJ (HSP40) bind partner chaperone DnaK (HSP70). This point is based on the following evidence: The QKRAA motif is expressed in the N-terminal part (J domain) of most bacterial DnaJ proteins; peptides containing the QKRAA motif bind DnaK (allowing its purification from total bacterial proteins).
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