 | Figure 1
Nature Medicine
4, 1313 - 1317 (1998)
doi:10.1038/3305
Neurogenesis in the adult human hippocampusPeter S. Eriksson, Ekaterina Perfilieva, Thomas Björk-Eriksson, Ann-Marie Alborn, Claes Nordborg, Daniel A. Peterson
& Fred H. Gage | | | | Figure 1. Newly generated cells can be detected in the adult human brain in patients
previously treated with BrdU.
a, The hippocampal region of the adult human brain immunoperoxidase-stained
for the neuronal marker NeuN. b, The hippocampal dentate gyrus granule
cell layer (GCL) visualized with immunoperoxidase staining for NeuN.
c, Differential interference contrast photomicrograph showing BrdU-labeled
nuclei (arrows) in the dentate granule cell layer (GCL). d, Differential
interference contrast photomicrograph showing a BrdU-labeled nucleus (arrow)
in the human dentate GCL. BrdU-positive nuclei have a rounded appearance and
resemble the chromatin structure of mature granule cells and are found within
the granule cell layer. e, Differential interference contrast photomicrograph
showing BrdU-positive cells (arrows) adjacent to the ependymal lining in the
subventricular zone of the human caudate nucleus. Cells with elongated nuclei
resembling migrating cells are in the rat subventricular zone (SVZ).
f, Differential interference contrast photomicrograph showing BrdU-positive
cells (arrows) with round to elongated nuclei in the subventricular zone of
the human caudate nucleus. All scale bars represent 50  m.
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