Fas ligand is a well-characterized apoptosis inducer. Here we demonstrate
that Fas ligand induces the processing and secretion of interleukin-1
(IL-1) in peritoneal exudate cells. This IL-1 secretion is independent
of IL-1 converting enzyme (caspase 1), yet it is inhibited by caspase
inhibitors, indicating that a caspase(s) in addition to IL-1 converting
enzyme can process IL-1. Inoculation of tumor cells expressing Fas ligand
into wild-type mice induces a massive neutrophil infiltration that is, in
contrast, suppressed in IL-1/ knockout mice. These results demonstrate
a newly discovered role for Fas ligand in inflammation, and challenge the
dogma that apoptosis does not induce inflammation.
release and inflammation induced by
the apoptosis inducer Fas ligand
(IL-1
/
