Nature Medicine
4, 18 - 19 (1998)
doi:10.1038/nm0198-018
From CRX to CRDMarc Abitbol
& Jean-Louis DufierFaculté dé Medecine NECKER, CERTO, 75015 Paris, France email: abitbol@ceylan.necker.fr Mutations in a homeodomain transcription factor that controls photoreceptor differentiation cause Cone-Rod Dystrophy, an inherited disease of retinal degeneration that results in blindness. REFERENCES
- Rosenfeld, P., McKusick, V., Amberger, J. & Dryja, T. Recent advances in the gene map of inherited eye disorders: primary hereditary diseases of the retina, choroid and vitreous. J. Med. Genet 31, 903−915 (1994). | PubMed | ISI | ChemPort |
- Dryja, T.P. & Li, T. Molecular genetics of retinitis pig-mentosa. Hum. Mol. Genet. 4, 1739−1743 (1995). | PubMed | ISI | ChemPort |
- Berson, E.L., Pigmentosa: unfolding its mystery. Proc. Natl. Acad. Sci. USA 93, 4526−4528 (1996). | Article | PubMed | ChemPort |
- Furukawa,T., Morrow, E.M. & Cepko, C.L., Crx, a novel otx-like homeobox gene, shows photorecep-tor-specific expression and regulates photoreceptor differentiation. Cell, 91, 531−541 (1997). | Article | PubMed | ISI | ChemPort |
- Freund, C.L. et al. Cone-Rod Dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor. Cell 91, 551−553 (1997). | Article |
- Cepko, C.L., Austin, C., Yang, X., Alexiades, M. & Ezzedine, D. Cell fate determination in the vertebrate retina. Proc. Natl. Acad. Sci. USA 93, 589−595 (1996). | Article | PubMed | ChemPort |
- Evans, K. et al. Genetic linkage of cone-rod retinal dystrophy to chromosome 19q and evidence for segregation distortion. Nature Genet. 6, 210−213 (1994). | Article | PubMed | ISI | ChemPort |
- Freund, C.L., Horsford, D.J. & Mclnnes, R.R. Transcription factors and the developing eye: a genetic perspective. Hum. Mol. Genet. 5, 1471−1488 (1996). | PubMed | ISI | ChemPort |
- Oliver, G. & Gruss, P. Current views on eye development. Trends Neurosci. 20, 415−421 (1997). | Article | PubMed | ISI | ChemPort |
- Rubboli, F. et al. A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms. Genes and Function 1, 205−213 (1997). | PubMed | ChemPort |
|