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Nature Medicine  3, 952 - 953 (1997)
doi:10.1038/nm0997-952

The reproductive side of leptin

Farid F. Chehab

Department of Laboratory Medicine, University of California, San Francisco San Francisco, California 94143, USA

Leptin's role in pregnancy may help unravel the mechanisms by which this protein regulates obesity in humans (pages 1029−1033).

REFERENCES
  1. Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425−432 (1994). | Article | PubMed  | ISI | ChemPort |
  2. Maffei, M. et al. Leptin levels in human and rodent: Measurement of plasma leptin and ob mRNA in obese and weight-reduced subjects. Nature Med. 1, 1155−1161 (1995). | Article | PubMed  | ISI | ChemPort |
  3. Halaas, J.L. et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269, 543−546 (1995). | PubMed  | ISI | ChemPort |
  4. Montague, C.T. et al. Congenital leptin deficiency is associated with severe early onset obesity in humans. Nature 387, 903−908 (1997). | Article | PubMed  | ISI | ChemPort |
  5. Chehab, F.F., Lim, M.E. & Lu, R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genet. 12, 318−320 (1996). | Article | PubMed  | ISI | ChemPort |
  6. Chehab, F.F., Mounzih, K., Lu, R. & Lim, M.E. Early onset of reproductive function in normal female mice treated with leptin. Science 275, 88−90 (1997). | Article | PubMed  | ISI | ChemPort |
  7. Kennedy, G.C. & Mitra, J. Body weight and food intake as initiating factors for puberty in the rat. J. Physiol. (London) 166, 408−418 (1969).
  8. Frisch, R.E. & McArthur, J.W. Menstrual cycles: Fatness as a determinant of minimum weight for height necessary for their maintenance or onset. Science 185, 949−951 (1974). | PubMed  | ISI | ChemPort |
  9. Masuzaki, H. et al. Non-adipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans. Nature Med. 3, 1029−1033 (1997). | Article | PubMed  | ISI | ChemPort |
  10. Schubring, C. et al. Levels of leptin in maternal serum, amniotic fluid, and arterial and venous cord blood: relation to neonatal and placental weight. J. Clin. Endocr. Met. 82, 448−483 (1997).
  11. Matsuda, J. et al. Serum leptin concentration in cord blood: Relationship to birth weight and gender. J. Clin. Endocr. Met. 82, 1642−1644 (1997). | Article | ISI | ChemPort |
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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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