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Nature Medicine  3, 831 - 832 (1997)
doi:10.1038/nm0897-831

Pain killers of the immune system

Burt Sharp1 & Tony Yakshz2

  1Institute for Brain and Immune Disorders Minneapolis Medical Research Foundation Minneapolis, Minnesota 55404, USA

  2Anesthesiology Research Laboratories University of California, San Diego, California 92093, USA

T lymphocytes produce opioid immunopeptides that control pain at sites of inflammation

REFERENCES
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  2. Schsfer, M., Carter, L. & Stein, C. Interleukin-1beta and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue. Proc. Natl. Acad. Sci. USA. 91, 4219−4223 (1994). | PubMed  | ISI |
  3. Mousa, S.A., Schsfer, M., Mitchell, W.M., Hassan, A.H.S. & Stein, C. Local upregulation of corticotropin-releasing hormone and interleukin-1 receptors in rats with painful hindlimb inflammation. European Journal of Pharmacology. 311, 221−231 (1996). | Article | PubMed  | ISI | ChemPort |
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  12. Yaksh, T.L. Substance P release from knee joint afferent terminals: modulation by opioids. Brain Res. 458, 319−324 (1988). | Article | PubMed  | ISI | ChemPort |
  13. Barber, A. mu- and k- opioid receptor agonists produce peripheral inhibition of neurogenic plasma extravasation in rat skin. Eur. J. Pharmacol. 236, 113−120 (1993). | Article | PubMed  | ISI | ChemPort |
  14. Russell, N.J.W., Schaible, H-G. & Schmidt, R. F. Opiates inhibit the discharges of fine afferent units from inflamed knee joint of the cat. Neurosci. Letts. 76, 107−112 (1987). | Article | ChemPort |
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ISSN: 1078-8956
EISSN: 1546-170X
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