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Nature Medicine  3, 725 - 726 (1997)
doi:10.1038/nm0797-725

Transglutaminase, gluten and celiac disease: Food for thought

Michael N. Marsh

University Department of Medicine Hope Hospital Salford M6 8HD Manchester, U.K.

Tansglutaminase is identified as the autoantigen or celiac disease (pages 797−801).

REFERENCES
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  2. Dieterich, W. et al. Identification of tissue transglutaminase as the autoantigen of coeliac disease. Nature Med. 3, 797−801 (1997). | Article | PubMed  | ISI | ChemPort |
  3. Peters, T.J. & Bjarnason, I. Coeliac syndrome: biochemical mechanisms and the missing peptidase hypothesis revisited. Gut 25, 913−918 (1984). | PubMed  | ISI | ChemPort |
  4. Marsh, M.N. Gluten, major histocompatibility complex, and the small intestine: A molecular and immunobiologic approach to the spectrum of gluten-sensitivity ("celiac sprue"). Gastroenterology 102, 330−354 (1992). | PubMed  | ISI | ChemPort |
  5. Trejdosiewicz, L.K. & Howdle, P.D. T-cell responses and cellular immunity in coeliac disease. In Coeliac Disease (ed. Howdle, P.D.) 251−272 (Balliere Tindall, Philadelphia, 1995). | ChemPort |
  6. Ferguson, A. Models of immunologically-driven small intestinal damage. In Immunopathology of the Small Intestine (ed. Marsh, M. N.) 225−252 (Wiley, Chichester, 1987).
  7. MacDonald, T.T. T cell-mediated intestinal injury. In Coeliac Disease (ed. Marsh, M.N.) 283−304 (Blackwell, Oxford, 1992).
  8. Marsh, M.N. & Cummins, A.G. The interactive role of mucosal T lymphocytes in intestinal growth, development and enteropathy. J. Gastroenterol. Hepatology, 8 270−278. | ChemPort |
  9. Nilsen, E.M., Lundkin, K.E. & Krajci, P. Gluten specific HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon-gamma. Gut 37, 766−776 (1995). | PubMed  | ISI | ChemPort |
  10. Marsh, M.N. Mucosal pathology in gluten sensitivity. In Coeliac Disease (ed. Marsh, M.N.) 136−191 (Blackwell, Oxford, 1992).
  11. Pender, S.L.F., Lionetti, P., Murch, S.H., Wathan, N. & MacDonald, T.T. Proteolytic degradation of intestinal mucosal extracellular matrix after lamina propria T cell activation. Gut 39, 284−290 (1996). | PubMed  | ISI | ChemPort |
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ISSN: 1078-8956
EISSN: 1546-170X
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