Journal home
Advance online publication
Current issue
Archive
Press releases
Supplements
Focuses
Guide to authors
Online submissionOnline submission
For referees
Free online issue
Contact the journal
Subscribe
Advertising
work@npg
Reprints and permissions
About this site
For librarians
 
NPG Resources
Nature
Nature Reviews
Nature Immunology
Nature Cell Biology
Nature Genetics
news@nature.com
Nature Conferences
Dissect Medicine
NPG Subject areas
Biotechnology
Cancer
Chemistry
Clinical Medicine
Dentistry
Development
Drug Discovery
Earth Sciences
Evolution & Ecology
Genetics
Immunology
Materials Science
Medical Research
Microbiology
Molecular Cell Biology
Neuroscience
Pharmacology
Physics
Browse all publications
News and Views
Nature Medicine  3, 610 - 611 (1997)
doi:10.1038/nm0697-610

Cytotrophoblasts: Masters of disguise

Christopher W.G. Redman

Nuffield Department of Obstetrics and Gynecology, John Radcliffe Hospital Oxford OX3 9DU, United Kingdom

Altered expression of adhesion molecules on fetal cytotrophoblasts is essential for development of a normal placenta and fails in pre-eclampsia.

REFERENCES
  1. Haig, D. Genetic conflicts in human pregnancy. Q. Rev. Biol. 68, 495−532 (1993). | Article | PubMed  | ISI | ChemPort |
  2. Pijnenborg, R., Robertson, W.B., Brosens, I. & Dixon, G. Trophoblast invasion and the establishment of haemochorial placentation in man and laboratory animals. Placenta 2, 71−92 (1981). | PubMed  | ISI | ChemPort |
  3. Zhou, Y. et al. Human cytotrophoblasts adopt a vascular phenotype as they differentiate. J. Clin. Invest. 99, 2139−2151 (1997). | PubMed  | ISI | ChemPort |
  4. Zhou, Y. Damsky, C.H. & Fosjer, S.J. Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. J. Clin. Invest. 99, 2152−2164 (1997). | PubMed  | ISI | ChemPort |
  5. Damsky, C.H., Fitzgerald, M.L. & Fisher, S.J. Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway in vivo. J. Clin. Invest. 89, 210−222 (1992). | PubMed  | ISI | ChemPort |
  6. Zhou, Y., Damsky, C.H., Chiu, K., Roberts, J.M. & Fisher, S.J. Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblasts. J. Clin. Invest. 91, 950−960 (1993) | PubMed  | ISI | ChemPort |
  7. Redman, C.W.G. Current topic: pre-eclampsia and the placenta. Placenta 12, 301−308 (1991). | PubMed  | ISI | ChemPort |
  8. Brosens, I.A. Robertson, W.B. & Dixon, H.G. The role of the spiral arteries in the pathogenesis of preeclampsia. Obstet. Gynecol. Annu. 1, 177−191 (1972). | PubMed  | ChemPort |
 Top
 Top
References
Previous | Next
Table of contents
Download PDFDownload PDF
Send to a friendSend to a friend
Save this linkSave this link

Open Innovation Challenges

  • Optimizing Sub-cellular Localization Tags

    • Deadline: Nov 29 2009
    • Reward: $20,000 USD

    The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression....

  • Single-cell Analysis Platform

    • Deadline: Dec 02 2009
    • Reward: $5,000 USD

    This Challenge is looking for novel approaches to analyzing changes at a single-cell level. This is...

naturejobs

References
Export citation
Export references
natureproducts

Search buyers guide:

 
ADVERTISEMENT
 
Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
Journal home | Advance online publication | Current issue | Archive | Press releases | Supplements | Focuses | For authors | Online submission | For referees | Free online issue | About the journal | Contact the journal | Subscribe | Advertising | work@npg | Reprints and permissions | About this site | For librarians
Nature Publishing Group, publisher of Nature, and other science journals and reference works©1997 Nature Publishing Group | Privacy policy