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Nature Medicine  3, 606 - 608 (1997)
doi:10.1038/nm0697-606

Progress of the smart bomb cancer virus

Scott W. Lowe

Cold Spring Harbor Laboratory Cold Spring Harbor, NY 11724

A mutant adenovirus capable of preferentially destroying cancer cells shows promise in preclinical studies (639−645).

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  2. Heise, C. et al. ONXY-015, an El B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nature Med. 3, 639−645 (1997). | Article | PubMed  | ISI | ChemPort |
  3. Weinberg, R. A. The cat and mouse games that genes, viruses, and cells play. Cell 88, 573−575 (1997). | Article | PubMed  | ISI | ChemPort |
  4. Lowe, S.W. & Ruley, H.E. Stabilization of the p53 tumor suppressor is induced by adenovirus E1A and accompanies apoptosis. Genes Dev. 7, 535−545 (1993). | PubMed  | ISI | ChemPort |
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  6. Debbas, M. & White, E. Wildtype p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev. 7, 546−554 (1993). | Article | PubMed  | ISI | ChemPort |
  7. Yew, P.R. & Berk, A.J. Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein. Nature 357, 82−85 (1992). | Article | PubMed  | ISI | ChemPort |
  8. Lowe, S.W., Ruley, H.E., Jacks, T. & Housman, D.E. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74, 954−967 (1993). | Article |
  9. Somasundaram, K. & E1-Deiry, W.S. Inhibition of p53-mediated transactivation and cell cycle arrest by E1 A through its p300/CBP-interacting region. Oncogene 14, 1047−1057 (1997). | Article | PubMed  | ISI | ChemPort |
  10. Dobner, T., Horikoshi, N., Rubenwolf, S. & Shenk, T. Blockage by adenovirus E41orf6 of transcriptional activation by the p53 tumor suppressor. Science 272, 1470−1473 (1996). | PubMed  | ISI | ChemPort |
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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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