Journal home
Advance online publication
Current issue
Archive
Press releases
Supplements
Focuses
Guide to authors
Online submissionOnline submission
For referees
Free online issue
Contact the journal
Subscribe
Advertising
work@npg
Reprints and permissions
About this site
For librarians
 
NPG Resources
Nature
Nature Reviews
Nature Immunology
Nature Cell Biology
Nature Genetics
news@nature.com
Nature Conferences
Dissect Medicine
NPG Subject areas
Biotechnology
Cancer
Chemistry
Clinical Medicine
Dentistry
Development
Drug Discovery
Earth Sciences
Evolution & Ecology
Genetics
Immunology
Materials Science
Medical Research
Microbiology
Molecular Cell Biology
Neuroscience
Pharmacology
Physics
Browse all publications
News and Views
Nature Medicine  3, 605 - 606 (1997)
doi:10.1038/nm0697-605

Fighting HIV-1 with IL-16

Michael Baier & Reinhard Kurth

Paul-Ehrlich-Institutm, 63225 Langen, Germany

Replication of HIV-1 is halted in human CD44 T cells engineered to express interleukin 16, suggesting a novel gene therapy approach to combat HIV infection (659−664).

REFERENCES
  1. Levy, A. J., Mackewicz, C. E. & Barker, E. Barker, E. Controlling HIV pathogenesis: the role of the non-cytotoxic anti-HIV response of CD8+ T cells. Science 17, 218−224 (1996).
  2. Cocchi, F. et al. Identification of RANTES, MIP-1alpha and MIP-1beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 270, 1811−1815 (1995). | PubMed  | ISI | ChemPort |
  3. Baier, M., Werner, A., Bannert, N., Metzner, K. & Kurth, R. HIV suppression by IL-16. Nature 378, 563 (1995). | Article | PubMed  | ISI | ChemPort |
  4. Zhou, P., Goldstein, S., Devadas, K., Tewari, D. & Notkins, A.L. Human CD4+ cells transfected with IL-16 cDNA are resistant to HIV-1 infection: inhibition of mRNA expression. Nature Med. 3, 659−664 (1997). | Article | PubMed  | ISI | ChemPort |
  5. Center, D.M., Kornfeld, H. & Cruikshank, W.W. Interleukin 16 and its function as a CD4 ligand. Immunol. Today 17, 476−481 (1996). | Article | PubMed  | ISI | ChemPort |
  6. Baier, M., Bannert, N., Werner, A., Lang, K. & Kurth, R. Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor. Proc Natl. Acad. Sci. USA (1997)in press.
  7. Benkirane, M.D., Corbeau, P., Housset, V. & Deveaux, C. An antibody that binds the immunoglobulin CDR3-like region of the CD4 molecule inhibits provirus transcription in HIV-infected T cells. EMBO J. 12, 4909−4921 (1993). | PubMed  | ISI | ChemPort |
  8. Tremblay, M., Meloche, S., Gratton, s., Wainberg, M.A. & Sekaly, R.-P. Association of p56-lck with the cytoplasmic domain of CD4 modulates HIV-1 expression. EMBO J. 13, 774−783 (1994). | PubMed  | ISI | ChemPort |
  9. Fauci, A.S. Host factors and the pathogenesis of HIV-induced disease. Nature 384, 529−534 (1996). | Article | PubMed  | ISI | ChemPort |
  10. Schmidtmayerova, H., Sherry, B. & Bukrinsky, M. Chemokines and HIV-replication. Nautre 382, 767 (1996). | Article | ChemPort |
  11. Guidotti, L.G. et al. Intracellular inactivation of the hepatitis B virus by cytotoxic T cells. Immunity 4, 25−36 (1996). | PubMed  | ISI | ChemPort |
 Top
 Top
References
Previous | Next
Table of contents
Download PDFDownload PDF
Send to a friendSend to a friend
Save this linkSave this link

Open Innovation Challenges

naturejobs

References
Export citation
Export references
natureproducts

Search buyers guide:

 
ADVERTISEMENT
 
Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
Journal home | Advance online publication | Current issue | Archive | Press releases | Supplements | Focuses | For authors | Online submission | For referees | Free online issue | About the journal | Contact the journal | Subscribe | Advertising | work@npg | Reprints and permissions | About this site | For librarians
Nature Publishing Group, publisher of Nature, and other science journals and reference works©1997 Nature Publishing Group | Privacy policy