Cleaning up on -catenin

Inactivation of the APC tumor suppressor gene in melanoma and colon cancer results in increased transcriptional activity mediated by -catenin.

1. Kinzler, K.W. & Vogelstein, B. Lessons from hereditary colorectal cancer. Cell 87, 159−170 (1996). | PubMed  | ISI | ChemPort |
2. Korinek, V. et al. Constitutive transcriptional activation by a -catenin−Tcf complex in APC-/-colon carcinoma. Science 275, 1784−1787 (1997). | Article | PubMed  | ISI | ChemPort |
3. Morin, P.J. et al. Activation of -catenin−Tcf signaling in colon cancer by mutations in -catenin or APC. Science 275, 1787−1790 (1997). | Article | PubMed  | ISI | ChemPort |
4. Rubinfeld, B. et al. Stabilization of -catenin by genetic defects in melanoma Cell lines. Science 275, 1790−1792 (1997). | Article | PubMed  | ISI | ChemPort |
5. Behrens, J. et al. Functional interaction of b-catenin with the transcription factor LEF-1. Nature 382, 638−642 (1996). | Article | PubMed  | ISI | ChemPort |
6. Molenaar, M. et al, Xtcf-3 transcription factor mediates -catenin-induced axis formation in Xenopus embryos. Cell 86, 391−399 (1996). | Article | PubMed  | ISI | ChemPort |
7. Takeda, H. et al. V-src kinase shifts the cadherin-based Cell adhesion from the strong to weak state and -catenin is not required for the shift. J. Cell Biol. 131, 1839−1847 (1995). | Article | PubMed  | ISI | ChemPort |
8. Hoschuetzky, H., Aberle, H. & Kemler, R. -Catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J. Cell Biol. 127, 1375−1380 (1994). | Article | PubMed  | ISI | ChemPort |
9. Shibata, T. et al. Dominant negative inhibition of the association between -catenin and c-erbB-2 by N-terminally deleted -catenin suppresses the invasion and metastasis of cancer Cells. Oncogene 13, 883−889 (1996). | PubMed  | ISI | ChemPort |

	Top

	Top