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Nature Medicine  3, 499 - 500 (1997)
doi:10.1038/nm0597-499

Cleaning up on bold beta-catenin

Yusuke Nakamura

Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108, Japan

Inactivation of the APC tumor suppressor gene in melanoma and colon cancer results in increased transcriptional activity mediated by beta-catenin.

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  2. Korinek, V. et al. Constitutive transcriptional activation by a beta-catenin−Tcf complex in APC-/-colon carcinoma. Science 275, 1784−1787 (1997). | Article | PubMed  | ISI | ChemPort |
  3. Morin, P.J. et al. Activation of beta-catenin−Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275, 1787−1790 (1997). | Article | PubMed  | ISI | ChemPort |
  4. Rubinfeld, B. et al. Stabilization of beta-catenin by genetic defects in melanoma Cell lines. Science 275, 1790−1792 (1997). | Article | PubMed  | ISI | ChemPort |
  5. Behrens, J. et al. Functional interaction of b-catenin with the transcription factor LEF-1. Nature 382, 638−642 (1996). | Article | PubMed  | ISI | ChemPort |
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  7. Takeda, H. et al. V-src kinase shifts the cadherin-based Cell adhesion from the strong to weak state and beta-catenin is not required for the shift. J. Cell Biol. 131, 1839−1847 (1995). | Article | PubMed  | ISI | ChemPort |
  8. Hoschuetzky, H., Aberle, H. & Kemler, R. beta-Catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J. Cell Biol. 127, 1375−1380 (1994). | Article | PubMed  | ISI | ChemPort |
  9. Shibata, T. et al. Dominant negative inhibition of the association between beta-catenin and c-erbB-2 by N-terminally deleted beta-catenin suppresses the invasion and metastasis of cancer Cells. Oncogene 13, 883−889 (1996). | PubMed  | ISI | ChemPort |
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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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