Nature Medicine
3, 443 - 446 (1997)
doi:10.1038/nm0497-443
Critical components of the female reproductive pathway are suppressed by the angiogenesis inhibitor AGM-1470Nancy Klauber1, 2, Richard M. Rohan1, Evelyn Flynn1
& Robert J. D'amato1
1Department of Surgery, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
2 Department of Surgery, Boston University Medical Center, Boston, Massachusetts 02118, USA Angiogenesis, the growth of new blood vessels, occurs normally in female reproductive organs. We tested the hypothesis that angiogenesis inhibition may affect fertility by studying the reproductive system in either pregnant or nonpregnant cycling mice after treatment with the angiogenesis inhibitor AGM-1470. Administration of AGM-1470 to pregnant mice resulted in complete failure of embryonic growth due to interference with decidualization, placental and yolk sac formation, and embryonic vascular development. When nonpregnant cycling female mice were chronically treated with AGM-1470, inhibition of endometrial maturation and corpora lutea was observed. These data suggest that processes in reproduction can be controlled through angiogenesis inhibition.
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