Provider: Nature Publishing Group Content: application/x-research-info-systems TY - JOUR AU - Zhang, Y. TI - Positional cloning of the mouse obese gene and its human homologue JO - Nature PY - 1994/// VL - 372 SP - 425 EP - 432 M3 - 10.1038/372425a0 N1 - 10.1038/372425a0 UR - http://dx.doi.org/10.1038/372425a0 ER - TY - JOUR AU - Halaas, J.L. TI - Weight-reducing effects of the plasma protein encoded by the obese gene JO - Science PY - 1995/// VL - 269 SP - 543 EP - 546 ER - TY - JOUR AU - Pelleymounter, M.A. TI - Effects of the obese gene product on body weight regulation in ob/ob mice JO - Science PY - 1995/// VL - 269 SP - 540 EP - 543 ER - TY - JOUR AU - Campfield, L.A. AU - Smith, F.J. AU - Guisez, Y. AU - Devos, R. AU - Burn, P. TI - Recombinant mouse ob protein: Evidence for a peripheral signal linking adiposity and central neural networks JO - Science PY - 1995/// VL - 269 SP - 546 EP - 549 ER - TY - JOUR AU - Schwartz, M.W. TI - Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice JO - Diabetes PY - 1996/// VL - 45 SP - 531 EP - 535 ER - TY - JOUR AU - Maffei, M. TI - Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects JO - Nature Med. PY - 1995/// VL - 1 SP - 1155 EP - 1161 M3 - 10.1038/nm1195-1155 N1 - 10.1038/nm1195-1155 UR - http://dx.doi.org/10.1038/nm1195-1155 ER - TY - JOUR AU - Considine, R.V. TI - Serum immunoreactive-leptin concentrations in normal-weight and obese humans JO - N. Engl. J. Med. PY - 1996/// VL - 334 SP - 292 EP - 295 M3 - 10.1056/NEJM199602013340503 N1 - 10.1056/NEJM199602013340503 UR - http://dx.doi.org/10.1056/NEJM199602013340503 ER - TY - JOUR AU - Coleman, D.L. TI - Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice JO - Diabetologia PY - 1978/// VL - 14 SP - 141 EP - 148 ER - TY - JOUR AU - Tartaglia, L.A. TI - Identification and expression cloning of a leptin receptor, OB-R JO - Cell PY - 1995/// VL - 85 SP - 1265 EP - 1271 ER - TY - JOUR AU - Lee, G.-H. TI - Abnormal splicing of the leptin receptor in diabetic mice JO - Nature PY - 1996/// VL - 379 SP - 632 EP - 635 M3 - 10.1038/379632a0 N1 - 10.1038/379632a0 UR - http://dx.doi.org/10.1038/379632a0 ER - TY - JOUR AU - Schwartz, M.W. AU - Boyko, E.J. AU - Kahn, S.E. AU - Ravussin, E. AU - Bogardus, C. TI - Reduced insulin secretion: An independent predictor of body weight gain JO - J. Clin. Endocrinol. Metab. PY - 1995/// VL - 80 SP - 1571 EP - 1576 M3 - 10.1210/jc.80.5.1571 N1 - 10.1210/jc.80.5.1571 UR - http://dx.doi.org/10.1210/jc.80.5.1571 ER - TY - JOUR AU - Swinburn, B.A. TI - Insulin resistance associated with lower rates of weight gain in Pima Indians JO - J. Clin. Invest. PY - 1991/// VL - 88 SP - 168 EP - 173 ER - TY - JOUR AU - Ravussin, E. TI - Reduced rate of energy expenditure as a risk factor for body-weight gain JO - N. Engl. J. Med. PY - 1988/// VL - 318 SP - 467 EP - 472 ER - TY - JOUR AU - Maffei, M. TI - The human obese gene: Isolation, characterization, identification of a DNA polymorphism and mutation screening in obese/diabetic subjects JO - Diabetes PY - 1996/// VL - 45 SP - 679 EP - 682 ER - TY - JOUR AU - Considine, R.V. TI - Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity JO - J. Clin. Invest. PY - 1995/// VL - 95 SP - 2986 EP - 2988 ER - TY - JOUR AU - Norman, R.A. TI - Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians JO - Diabetes PY - 1996/// VL - 45 SP - 1229 EP - 1232 ER - TY - JOUR AU - Stirling, B. TI - Identification of microsatellite markers near the human OB gene and linkage studies in NIDDM-affected sib pairs JO - Diabetes PY - 1995/// VL - 44 SP - 999 EP - 1001 ER - TY - JOUR AU - Reed, D.R. TI - Extreme obesity may be linked to markers flanking the human OB gene JO - Diabetes PY - 1996/// VL - 45 SP - 691 EP - 694 ER - TY - JOUR AU - Clement, K. TI - Indication of linkage of the human OB gene region with extreme obesity JO - Diabetes PY - 1996/// VL - 45 SP - 687 EP - 690 ER - TY - JOUR AU - Saladin, R. TI - Transient increase in obese gene expression after food intake or insulin administration JO - Nature PY - 1995/// VL - 377 SP - 527 EP - 529 M3 - 10.1038/377527a0 N1 - 10.1038/377527a0 UR - http://dx.doi.org/10.1038/377527a0 ER - TY - JOUR AU - Kolaczynski, J.W. TI - Acute and chronic effect of insulin on leptin production in humans: Studies in vivo and in vitro JO - Diabetes PY - 1996/// VL - 45 SP - 699 EP - 701 ER - TY - JOUR AU - Stephens, T.W. TI - The role of neuropeptide Y in the antiobesity action of the obese gene product JO - Nature PY - 1995/// VL - 377 SP - 530 EP - 532 M3 - 10.1038/377530a0 N1 - 10.1038/377530a0 UR - http://dx.doi.org/10.1038/377530a0 ER - TY - JOUR AU - Schwartz, M.W. AU - Peskind, E. AU - Raskind, M. AU - Boyko, E.J. AU - Porte, D. TI - Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans JO - Nature Med. PY - 1996/// VL - 2 SP - 589 EP - 592 M3 - 10.1038/nm0596-589 N1 - 10.1038/nm0596-589 UR - http://dx.doi.org/10.1038/nm0596-589 ER - TY - JOUR AU - Collins, S. TI - Leptin stimulates sympathetic outflow to brown adipose tissue JO - Nature PY - 1996/// VL - 380 SP - EP - 677 ER - TY - JOUR AU - Spraul, M. TI - Reduced sympathetic nervous activity: A potential mechanism predisposing to body weight gain JO - J. Clin. Invest. PY - 1993/// VL - 92 SP - 1730 EP - 1735 ER - TY - JOUR AU - Neel, J.V. TI - Diabetes mellitus: A [ldquo]thrifty[rdquo] genotype rendered detrimental by [ldquo]progress[rdquo] JO - Am. J. Hum. Genet. PY - 1962/// VL - 14 SP - 353 EP - 362 ER - TY - JOUR AU - Ahima, R.S. TI - Role of leptin in the neuroendocrine response to fasting JO - Nature PY - 1996/// VL - 382 SP - 250 EP - 252 M3 - 10.1038/382250a0 N1 - 10.1038/382250a0 UR - http://dx.doi.org/10.1038/382250a0 ER - TY - JOUR AU - Lillioja, S. TI - Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus JO - N. Engl. J. Med. PY - 1993/// VL - 329 SP - 1988 EP - 1992 M3 - 10.1056/NEJM199312303292703 N1 - 10.1056/NEJM199312303292703 UR - http://dx.doi.org/10.1056/NEJM199312303292703 ER -