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Nature Medicine  3, 154 - 155 (1997)
doi:10.1038/nm0297-154

Platelet stimulating agents — off the launching pad

Stephen D. Nimer

Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA

Promising clinical trial data suggest that thrombopoietic growth factors may soon enter clinical practice.

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  2. Gurney, A.L., Carver-Moore, K., de Sauvage, F.J. & Moore, M.W. Thrombocytopenia in c-mpl-deficient mice. Science 265, 1445−1447 (1994). | PubMed  | ISI | ChemPort |
  3. de Sauvage, F. et al. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J. Exp. Med. 183, 651−656 (1996). | PubMed  | ChemPort |
  4. Kaushansky, K. et al. Thrombopoietin, the mpl lig-and, is essential for full megakaryocyte develop-ment. Proc. Natl. Acad. Sci. USA 92, 3234−3238 (1995). | PubMed  | ChemPort |
  5. Shivdasani, R.A. et al. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MCDF in megakary-ocyte development. Cell 81, 695−704 (1995). | PubMed  | ISI | ChemPort |
  6. Tepler, I. et al. A randomized placebo-controlled trial of recombinant human interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy. Blood 87, 3607−3614 (1996). | PubMed  | ISI | ChemPort |
  7. Basser, R.L. et al. Thrombopoietic effects of pegy-lated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer. Lancet 348, 1279−1281 (1996). | Article | PubMed  | ISI | ChemPort |
  8. Archimbaud, E. et al. A randomized, double-blind, placebo-controlled study using PEG-rHuMGDF as an adjunct to chemotherapy for adults with de novo acute myeloid leukemia (AML): Early results (Abstr.). Blood 88, (Suppl. 1), 447a (1996).
  9. Vadhan-Raj, S. et al. Phase l-ll investigation of re-combinant human thrombopoietin (rhTPO) in pa-tients with sarcoma receiving high dose chemotherapy (CT) with adriamycin (A) and ifos-famide (I) (Abstr.). Blood 88, (Suppl. 1), 448a (1996).
  10. O'Malley, C.J. et al. Administration of pegylated recombinant human megakaryocyte growth and development factor to humans stimulates the production of functional platelets that show no evidence of in vitro activation. Blood 88, 3288−3298 (1996). | PubMed  | ChemPort |
  11. Groopman, J.E., Mitsuyasu, R.T., DeLeo, M.J., Oette, D.H. & Golde, D.W. Effect of recombinant human granulocyte-macrophage colony-stimulating factor on myelopoiesis in the acquired immunodeficiency syndrome. New Engl. J. Med. 317, 593−598 (1987). | PubMed  | ISI | ChemPort |
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ISSN: 1078-8956
EISSN: 1546-170X
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