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Nature Medicine  3, 151 - 152 (1997)
doi:10.1038/nm0297-151

Breast cancer and osteolytic metastases: Can bisphosphonates help?

Ethel S. Siris

Department of Medicine College of Physicians and Surgeons of Columbia University New York, New York 10032, USA

Intravenous infusions of pamidronate ameliorate the skeletal complications of breast cancer metastases to bone.

REFERENCES
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  2. Hortobagyi, G.N. et al. Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. N. Engl. J. Med. 335, 1785−1791 (1996). | Article | PubMed  | ISI | ChemPort |
  3. van Breukelen, F.J.M. et al. Inhibition of osteolytic bone lesions by (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD). Lancet 1, 803−805 (1979). | Article | PubMed  | ChemPort |
  4. Siris, E.S., Hyman, G.A. & Canfield, R.E. Effects of dichloromethylene bisphosphonate in women with breast cancer metastatic to the skeleton. Am. J. Med. 74, 401−406 (1983). | Article | PubMed  | ISI | ChemPort |
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  7. Fleisch, H. & Russell, R.G.G. Pyrophosphate and polyphosphate. in Encyclopedia (Int.) of Pharma-cology and Therapeutics, Section 51. Pharmacology of the Endocrine System and Related Drugs. 61−100 (Pergamon, Oxford, New York, 1970).
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  10. Kanis, J.A. Pathophysiology and Treatment of Paget's Disease of Bone. 159−216 (Dunitz, London, 1991).
  11. Jacobs, T.P. et al. Neoplastic hypercalcemia: Physio-logic response to intravenous etidronate disodium. Am. J. Med. 82 (Suppl. 2A), 42−50 (1987). | Article | PubMed  | ISI | ChemPort |
  12. Nussbaum, S.R. et al. Single-dose intravenous ther-apy with pamidronate for the treatment of hypercalcemia of malignancy: Comparison of 30,60, and 90 mg dosages. Am. J. Med. 95, 297−304 (1993). | PubMed  | ISI | ChemPort |
  13. Berenson, J.R. et al. Efficacy of pamidronate in re-ducing skeletal events in patients with advanced multiple myeloma. N. Engl. J. Med. 334, 488−493 (1996). | Article | PubMed  | ISI | ChemPort |
  14. Morton, A.R. et al. Sclerosis of lytic bone metastases after disodium aminohydroxy-propylidene bisphos-phonate (APD) in patients with breast carcinoma. Br. Med. J. 297, 772−773 (1988). | ISI | ChemPort |
  15. Glover, D. et al. Intravenous pamidronate sodium treatment of bone metastases in patients with breast cancer: A dose seeking study. Cancer 74, 2949−2955 (1994). | PubMed  | ISI | ChemPort |
  16. Rodan, G.A. & Rodan, S.B. Osteoporosis: Etiology, Diagnosis and Management, (eds. Riggs, B.L. & Melton, L.J.) 12 (Raven, New York, 1988).
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