Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Terms of attachment: SPARC and tumorigenesis

Nature Medicine volume 3, pages 144–146 (1997)Cite this article

Inhibition of SPARC expression suppresses the tumorigenicity of human melanoma Cells in nude mice (pages 171–176).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Ledda, M.F. et al. Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells. Nature Med. 3, 171–176 (1997).

    Article  CAS  Google Scholar 

  2. Lane, T.F., & Sage, E.H. The biology of SPARC, a protein that modulates cell-matrix interactions. FASEB J. 8, 163–173 (1994).

    Article  CAS  Google Scholar 

  3. Porter, P.L., Sage, E.H., Lane, T.F., Funk, S.E. & Gown, A.M. Distribution of SPARC in normal and neoplastic human tissue. J. Histochem. Cytochem 43, 791–800 (1995).

    Article  CAS  Google Scholar 

  4. Sage, E.H. & Bornstein, P., Extracellular proteins that modulate cell-matrix interactions: SPARC, tenascin, and thrombospondin. J. Biol. Chem. 266, 14831–14834 (1991).

    CAS  PubMed  Google Scholar 

  5. Bornstein, P. Diversity of function is inherent in matricellular proteins: An appraisal of thrombospondin 1. J. Cell Biol. 130, 503–506 (1995).

    Article  CAS  Google Scholar 

  6. Hohenester, E. et al. Structure of a novel extracellular Ca2+-binding module in BM-40. Nature Struct. Biol. 3, 67–73 (1996).

    Article  CAS  Google Scholar 

  7. Sage, E.H. Angiogenesis inhibition in the context of endothelial cell biology. Adv. Oncol. 12, 17–29 (1996).

    Google Scholar 

  8. Hanahan, D. & Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86, 353–364 (1996).

    Article  CAS  Google Scholar 

  9. Roberts, D.D. Regulation of tumor growth and metastasis by thrombospondin-1. FASEB J. 10, 1183–1191 (1996).

    Article  CAS  Google Scholar 

  10. Pepper, M.S., Montesano, R., Mandriota, S.J., Orci, L. & Vassalli, J.D. Angiogenesis: A paradigm for balanced extracellular proteolysis during cell migration and morphogenesis. Enzyme Protein 49, 138–162 (1996).

    Article  CAS  Google Scholar 

  11. Huttenlocher, A., Sandborg, R.R. & Horwitz, A.F., Adhesion in cell migration. Curr. Opin. Cell Biol. 7, 697–706 (1995).

    Article  CAS  Google Scholar 

  12. Ruoslahti, E. & Öbrink, B., Common principles in cell adhesion. Exp. Cell Res. 227, 1–11 (1996).

    Article  CAS  Google Scholar 

  13. Brooks, P.C. et al. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin αv,β3 . Cell 85, 683–693 (1996).

    Article  CAS  Google Scholar 

  14. Iruela-Arispe, M.L., Vernon, R.B., Wu, H., Jaenisch, R. & Sage, E.H. Type I collagen-deficient mov 13 mice do not retain SPARC in the extracellular matrix: Implications for fibroblast function. Dev. Dyn. 207, 171–183 (1996).

    Article  CAS  Google Scholar 

  15. Schwartz, M.A., Schaller, M.D. & Ginsberg, M.H., Emerging paradigms of signal transduction. Annu. Rev. Cell Dev. Biol. 11, 549–599 (1995).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biological Structure, University of Washington School of Medicine, Seattle, Washington, 98195, USA

    E. Helene Sage

Authors
  1. E. Helene Sage
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Helene Sage, E. Terms of attachment: SPARC and tumorigenesis. Nat Med 3, 144–146 (1997). https://doi.org/10.1038/nm0297-144

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0297-144

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing