HIV-1 induction of CD40 on endothelial cells promotes the outgrowth of AIDS-associated B-cell lymphomas

1. Gaidano, G. & Dalla-Favera, A. Molecular pathogenesis of AIDS-related lym-phomas. Adv. Cancer Research 67, 113−153 (1995). | ISI | ChemPort |
2. Beral, V., Peterman, T., Berkelman, R. & Jafe, H. AIDS-associated non-Hodgkin lymphoma. Lancet 337, 805−809 (1991). | Article | PubMed  | ISI | ChemPort |
3. Shiramizu, B., Herndier, B., Meeker, T. & McGrath, M. Molecular and immunophe-notypic characterization of AIDS-associated, Epstein-Barr virus-negative, polyclonal lymphoma. J. Clin. Oncol. 10, 383−389 (1992). | PubMed  | ISI | ChemPort |
4. Delecluse, H. et al. Variable morphology of human immunodeficiency virus-associated lymphomas with c-myc rearrangements. Blood 82, 552−563 (1993). | PubMed  | ISI | ChemPort |
5. Astrin, S.M., Schattner, E., Laurence, J., Lebman, R.I. & Rodriguez-Alfageme, C. Does HIV infection of B lymphocytes initiate AIDS lymphoma? Detection by PCR of viral sequences in lymphoma tissue. Cur. Top. Microbiol. Immunol. 182, 399−407 (1992). | ChemPort |
6. Prevot, S., Raphael, M., Fournier, J.G. & Diebold, J. Detection by in situ hybridization of HIV and c-myc RNA in tumor cells of AIDS-related B-cell lymphomas. Histopathology 22, 151−156 (1993). | PubMed  | ISI | ChemPort |
7. Groopman, J.E. et al. Pathogenesis of B cell lymphoma in a patient with AIDS. Blood 67, 612−615 (1986). | PubMed  | ISI | ChemPort |
8. Pellici, G. et al. Multiple monoclonal B-cell expansions and c-myc oncogene re arrangements in acquired immune deficiency syndrome related lymphoproliferative disorders: Implications for lymphomagenesis. J. Exp. Med. 164, 2049−2076 (1986). | PubMed  | ISI | ChemPort |
9. Subar, M., Neri, A., Inghirami, C., Knowles, D.M. & Dalla-Favera, R. Frequent c-myc oncogene activation and infrequent presence of Epstein-Barr virus genome in AIDS-associated lymphoma. Blood 72, 667−671 (1988). | PubMed  | ISI | ChemPort |
10. Caidano, G. et al. In vitro establishment of AIDS-related lymphoma Cell lines: Phenotypic characterization, oncogene and tumour suppressor gene lesions, and heterogeneity in Epstein-Barr virus infection. Leukemia 7, 1621 1629 (1993).
11. Jacobsen, K. & Osmond, D.G. Microenvironmental organization and stromal cell associations of B lymphocyte precursor cells in mouse bone marrow. Eur. J. Immunol. 20, 2395−2398 (1990). | PubMed  | ISI | ChemPort |
12. Wolf, M.L., Buckley, J.A., Goldfarb, A., Law, C.L. & LeBien, T.W. Development of a bone marrow culture for maintenance and growth of normal human B-cell precursors. J. Immunol. 147, 3324−3330 (1991). | PubMed  | ISI | ChemPort |
13. Larvis, L.J. & LeBien, T.W. Stimulation of human bone marrow stromal cell tyrosine kinases and IL-6 production by contact with B lymphocytes. J. Immunol. 155, 2359−2368 (1995). | PubMed  |
14. Campana, D. et al. Prolonged survival of B-lineage acute lymphoblastic leukemia cells is accompanied by overexpression of bcl-2 protein. Blood 81, 1025−1031 (1993). | PubMed  | ISI | ChemPort |
15. Freedman, A.S. Expression and function of adhesion receptors on normal B-cells and B-cell non-Hodgkin's lymphomas. Semin. Hematology 30, 318−328 (1993). | ISI | ChemPort |
16. Manabe, A. et al. Adhesion-dependent survival of normal and leukemic human B lymphoblasts on bone marrow stromal cells. Blood 83, 758−766 (1994). | PubMed  | ISI | ChemPort |
17. Panayiotidis, P., Jones, D., Ganeshaguru, K., Foreni, L. & Hoffbrand, A.V. Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro. Br. J. Haematol. 92, 97−103 (1996). | Article | PubMed  | ISI | ChemPort |
18. Dittel, B.N., McCarthy, J., Wayner, E.A. & LeBien, T.W. Regulation of human B-cell precursor adhesion to bone marrow stromal cells by cytokines that exert opposing effects on the expression of vascular cell adhesion molecule-1 (VCAM-1). Blood 81, 2272−2282 (1993). | PubMed  | ISI | ChemPort |
19. Moses, A.V. et al. HIV infection of bone marrow endothelium reduces induction of stromal hematopoietic growth factors. Blood 87, 919−925 (1996). | PubMed  | ISI | ChemPort |
20. Kellog, D.E. & Kwok, S. Detection of human immunodeficiency virus. in PCR Protocols: A Guide to Methods and Applications. (eds. Innes, M.A., Gelfand, D.H., Sninsky, J.J. & White, T.J.) 337−347 (Academic Press, New York, 1990).
21. Telenti, A., Marshall, W.F. & Smith, T.F. Detection of Epstein-Barr virus by poly-merase chain reaction. J. Clin. Microbiol. 28, 2187−2190 (1990). | PubMed  | ISI | ChemPort |
22. Moore, P.S. & Chang, Y. Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infection. N. Engl. J. Med. 332, 1181−1185 (1995). | Article | PubMed  | ISI | ChemPort |
23. Moses, A.V., Bloom, F.E., Pauza, C.D. & Nelson, J.A. Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylce-ramide-independent mechanism. Proc. Notl. Acad. Sci. USA 90, 10474−10478 (1993). | ChemPort |
24. Moses, A.V. et al. Sequences regulating tropism of HIV-1 for brain capillary endothelial cells map to a unique region on the viral genome. J. Virol. 70, 3401−3406 (1996). | PubMed  | ISI | ChemPort |
25. Ryan, D.H., Nucci, B.L., Abbound, C.N. & Winslow, J.M. Cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B-Cell precursors to cultured bone marrow adherent Cells. J. Clin. Invest. 88, 995−1004 (1991). | PubMed  | ISI | ChemPort |
26. Freedman, A.S. et al. Follicular non-Hodgkin's lymphoma cell adhesion to normal germinal centers and neoplastic follicles involves very late antigen-4 and vascular cell adhesion molecule-1. Blood 79, 206−212 (1992). | PubMed  | ISI | ChemPort |
27. Simmonds, P.J. et al. Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells. Blood 80, 388−395 (1992). | PubMed  |
28. Tang, J., Scott, G. & Ryan, D.H. Subpopulations of bone marrow fibroblasts support VLA-4-mediated migration of B-cell precursors. Blood 82, 3415−3423 (1993). | PubMed  | ISI | ChemPort |
29. Moses, A.V., Stenglein, S.C. & Nelson, J.A. HIV infection of the brain microvascula-ture and its contribution to the AIDS dementia complex. J. NeuroAIDS 1, 85−99 (1996).
30. Wong, D. & Dorovtni-Zis, K. Expression of vascular cell adhesion molecuie-1 (VCAM-1) by human brain microvessel endothelial cells in primary culture. Microvasc. Res. 49, 325−339 (1995). | Article | PubMed  | ISI | ChemPort |
31. Hollenbaugh, D. et al. Expression of functional CD40 by vascular endothelial cells. J. Exp. Med. 182, 33−4O (1995). | PubMed  | ISI | ChemPort |
32. Karmann, K., Hughes, C.C.W., Schechner, J., Fanslow, W.C. & Pober, J.S. CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression. Proc. Notl. Acad. Sci. USA 92, 4342−4346 (1995). | ChemPort |
33. Yellin, M.J. et al. Functional interactions of T cells with endothelial cells: The role of CD40L-CD40-mediated signals. J. Exp. Med. 182, 1857−1864 (1995). | PubMed  | ISI | ChemPort |
34. Yellin, M.J. et al. Ligation of CD40 on fibroblasts induces CD54 (ICAM-1) and CD106 (VCAM-1) up-regulation and IL-6 production and proliferation. J. Leukocyte Biol. 58, 209−216 (1995). | PubMed  | ISI | ChemPort |
35. Graf, D., Korthauer, U., Mages, H.W., Senger, G. & Kroczek, R.A. Cloning of TRAP, a ligand for CD40 on human T cells. Eur. J. Immunol. 22, 3191- (1992). | PubMed  | ISI | ChemPort |
36. Pinchuk, L.M. et al. Functional CD40 ligand expressed by human blood dendritic cells is up-regulated by CD40 ligation. J. Immunol. 157, 4363−4370 (1996). | PubMed  | ISI | ChemPort |
37. Mach, F. et al. Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, smooth muscle cells, and macrophages: Implications for CD40-CD40L signalling in atherosclerosis. Proc. Notl. Acad. Sci. USA 94, 1931−1936 (1997). | Article | ChemPort |
38. Crammer, A.C. et al. The CD40 Ligand expressed by human B cells costimulates B cell responses. J. Immunol. 154, 4996−5010 (1995). | PubMed  |
39. Castle, B.E. et al. Regulation of expression of the ligand for CD40 on T helper lymphocytes. J. Immunol. 151, 1777−1788 (1993). | PubMed  | ISI | ChemPort |
40. Chang, H-K., Gallo, R.C. & Ensoli, B., Regulation of cellular gene expression and function by the human immunodeficiency virus type 1 tat protein. J. Biomed. Sci. 2, 189−202 (1995). | PubMed  | ChemPort |
41. Harris, M. From negative factor to a critical role in viral pathogenesis: The changing fortunes of nef. J. Cen. Virol. 77, 2379−2392 (1996). | ChemPort |
42. Cohen, E.A. et al. Identification of HIV-1 vpr product and function. J. Aquired Immune Defic. Syndr. 3, 11−18 (1990). | ChemPort |
43. Wang, F. et al. Epstein-Barr virus latent membrane protein (LMP 1) and nuclear proteins 2 and 3c are effectors of phenotypic changes in B lymphocytes: EBNA 2 and LMP 1 cooperatively induce CD23. J. Virol. 64, 2309−2318 (1990). | PubMed  | ISI | ChemPort |
44. Pammer, J. et al. CD40 antigen is expressed by endothelial cells and tumor cells in Kaposi's sarcoma. Am. J. Pathol. 148, 1387−1396 (1996). | PubMed  | ISI | ChemPort |
45. Broshoff, C. et al. Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nature Med. 1, 1274−1278 (1995). | Article | PubMed  | ISI | ChemPort |
46. Gruss, H.-J. & Dower, S.K., Tumor necrosis factor ligand superfamily: Involvement in the pathology of malignant lymphomas. Blood 85, 3378−3404 (1995). | PubMed  | ISI | ChemPort |
47. Wiley, C.A., Schrier, R.D., Nelson, J.A., Lampert, P.W. & Oldstone, M.B.A. Cellular localization of human immunodeficiency virus infection within the brains of acquired immunodeficiency patients. Proc. Notl. Acad. Sci. USA 83, 7089−7093 (1986). | ChemPort |
48. Steffan, A-M. et al. Primary cultures of endothelial cells from the human liver sinusoid are permissive for human immunodeficiency virus type 1. Proc. Notl. Acad. Sci. USA 89, 1582−1586 (1992). | ChemPort |
49. Green, D.F., Resnick, L. & Bourgoignie, J.J. HIV infects glomerular endothelial and mesangial but not epithelial cells in vitro. Kidney Int. 41, 956−960 (1992). | PubMed  | ISI | ChemPort |
50. Rettig, M.B. et al. Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients. Science 276, 1851−1854 (1997). | Article | PubMed  | ISI | ChemPort |
51. Gallo, R.C. et al. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science 224, 500−503 (1984). | PubMed  | ChemPort |
52. Cann, A.J. et al. Human immunodeficiency virus type 1 T-cell tropism is determined by events prior to provirus formation. J. Virol. 64, 4735−4742 (1990). | PubMed  | ISI | ChemPort |
53. Levy, J.A. & Shimabukuro, J. Recovery of AIDS-associated retroviruses from patients with AIDS or AIDS-related conditions and from clinically healthy individuals. J. Infect. Dis. 152, 734−738 (1995).
54. Koyanagi, S. et al. Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms. Science 236, 819−836 (1987). | PubMed  | ISI |
55. Cheng-Mayer, C., Weiss, C., Seto, D. & Levy, J.A. Isolates of human immunodeficiency virus type 1 from the brain may constitute a special group of the AIDS virus. Proc. Notl. Acad. Sci. USA 86, 8575−8579 (1989). | ChemPort |

	Top

	Top