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Nature Medicine  3, 1080 - 1081 (1997)
doi:10.1038/nm1097-1080

Diabetes in midlife: Planting genetic time bombs

Stephen O'Rahilly

Departments of Medicine and Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Cambridge, CB2 2QQ, U.K.

Two mouse models of non-insulin-dependent diabetes show many similarities to the human disease (pages 1096−1101).

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  2. Stenbit, A.E. et al. GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes. Nature Med. 3, 1096−1101 (1997). | Article | PubMed  | ISI | ChemPort |
  3. Brüning, J.C. et al. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 88, 561−572 (1997). | Article | PubMed  | ISI | ChemPort |
  4. Patti, M.E. & Kahn, C.R. Lessons from transgenic and knockout animals about non-insulin-dependent diabetes meilitus. Trends in Endocrinology and Metabolism 7, 311−319 (1996). | Article | ISI | ChemPort |
  5. Defronzo, R.A. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 37, 667−686 (1988). | PubMed  | ISI | ChemPort |
  6. Accili, D. et al. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nature Genet. 12, 106−109 (1996). | Article | PubMed  | ISI | ChemPort |
  7. Araki, E., Lipes, M.A. & Patti, M.E. Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene. Nature 372, 186−190 (1994). | Article | PubMed  | ISI | ChemPort |
  8. Katz, E.B., Stenbit, A.E., Hatton, K., DePinho, R. & Charron, M.J. Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4. Nature 377, 151−155 (1995). | Article | PubMed  | ISI | ChemPort |
  9. Terauchi, Y. et al. Development of non-insulin-dependent diabetes mellitus in double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes: Genetic reconstitution of diabetes as a polygenic disease. J. Clin. Invest. 99, 861−866 (1997). | PubMed  | ISI | ChemPort |
  10. Chung, W.K. et al. Genetic modifiers of Lepr(fa) associated with variability in insulin production and susceptibility to NIDDM. Genomics 41, 332−344 (1997). | Article | PubMed  | ISI | ChemPort |
  11. Hales, C.N. & Barker, D.J.P. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35, 595−601 (1992). | PubMed  | ISI | ChemPort |
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Nature Medicine
ISSN: 1078-8956
EISSN: 1546-170X
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