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Nature Medicine  3, 24 - 25 (1997)
doi:10.1038/nm0197-24

Give the embryo a chance

Judith G. Hall

Department of Pediatrics British Columbia's Children's Hospital Vancouver, BC, Canada V6H 3V4

Inositol prevents neural tube defects in a mouse model of folate-resistant spina bifida (pages 60−66).

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  2. Czeizel, A.E. & Dunda, I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N. Engl. J. Med. 327, 1832−1835 (1992). | PubMed  | ISI | ChemPort |
  3. Butterworth, C.E. & Bendich, A. Folic acid and the prevention of birth defects. Annu. Rev. Nutr. 16, 73−97 (1996). | Article | PubMed  | ISI | ChemPort |
  4. Greene, N.D.E. & Copp, A.J. Inositol prevents folate-resistant neural tube defects in the mouse. Nature Med. 3, 60−66 (1997). | Article | PubMed  | ISI | ChemPort |
  5. Zhao, Q., Behringer, R.R. & de Crombrugghe B., Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene. Nature Genet. 13, 275−283 (1996). | Article | PubMed  | ISI | ChemPort |
  6. Oakley, G.P.Jr, Erickson, J.D. & Adams, M.J. Urgent need to increase folic acid consumption. JAMA 274, 1717−1718 (1995). | Article | PubMed  | ISI |
  7. Van Allen, M.I. et al. Evidence for multi-site closure of the neural tube in humans. Am. J. Med. Genet. 47, 723−743 (1993). | PubMed  | ChemPort |
  8. Seller, M.J., Vitamins, folic acid and the cause and prevention of neural tube defects. Ciba Found. Symp. 181, 161−179 (1994). | PubMed  | ISI | ChemPort |
  9. Motulsky, A.G. Nutritional ecogenetics: Homocysteine-related arteriosclerotic vascular disease, neural tube defects, and folic acid. Am. J. Hum. Genet. 58, 17−20 (1996). | PubMed  | ISI | ChemPort |
  10. Jennings, E. Folic acid as a cancer-preventing agent. Med. Hypotheses 45, 297−303 (1995). | PubMed  | ISI | ChemPort |
  11. Jacques, P.F. et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93, 7−9 (1996). | PubMed  | ISI | ChemPort |
  12. Rothman, K.J. et al. Teratogenicity of high vitamin A intake. N. Engl. J. Med. 333, 1369−1373 (1995). | Article | PubMed  | ISI | ChemPort |
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ISSN: 1078-8956
EISSN: 1546-170X
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