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Volume 23 Issue 7, July 2017

By performing stepwise treatment with growth factors and WNT pathway modulators, Crespo et al. (p 878) design a protocol to generate colonic organoids from human induced pluripotent stem cells (iPSCs). They apply this approach to derive organoids from iPSCs from patients with familial adenomatous polyposis (FAP). A drug screen using these organoids indicates that the antibiotic geneticin suppresses abnormal WNT signaling in organoids derived from FAP cells bearing ATM mutations. The cover image depicts a confocal projection of FAP-iPSC-derived colonic organoids, with colon marker CDX2 and proliferation marker CD1 false-colored in green and red, respectively. DAPI, blue. Image credit, Miguel Crespo. Artwork, Erin Dewalt.

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