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Obesity: will withaferin win the war?

A new study shows that withaferin A, a steroidal lactone isolated from Withania somnifera, can exert profound metabolic benefits in mice, including body-weight loss, reduced hepatic steatosis and improved glucose control.

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Figure 1: Structure, molecular targets and physiological effects of withaferin A in mice with DIO.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Matthias H Tschöp.

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Matthias Tschöp is a scientific advisor to Novo Nordisk, ERX and Bionorica.

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Pfluger, P., Tschöp, M. Obesity: will withaferin win the war?. Nat Med 22, 970–971 (2016). https://doi.org/10.1038/nm.4182

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