A new study of the pathogenesis of systemic lupus erythematosus (SLE) highlights the importance of mitochondria and mitochondrial reactive oxygen species (ROS) in the generation of neutrophil extracellular traps (NETs) that have the enhanced potential to elicit interferon-induced gene expression.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Brinkmann, V. & Zychlinsky, A. J. Cell Biol. 198, 773–783 (2012).
Lood, C. et al. Nat. Med. 22, 151–158 (2016).
Garcia-Romo, G.S. et al. Sci. Transl. Med. 3, 73ra20 (2011).
Fernandez-Boyanapalli, R.F. et al. J. Allergy Clin. Immunol. 135, 517–527.e512 (2015).
Douda, D.N., Khan, M.A., Grasemann, H. & Palaniyar, N. Proc. Natl. Acad. Sci. USA 112, 2817–2822 (2015).
Remijsen, Q. et al. Cell Res. 21, 290–304 (2011).
Gros, F. & Muller, S. Br. J. Pharmacol. 171, 4337–4359 (2014).
Bhattacharya, A. et al. Cell Rep. 12, 1731–1739 (2015).
Diana, J. et al. Nat. Med. 19, 65–73 (2013).
Wong, S.L. et al. Nat. Med. 21, 815–819 (2015).
Wang, H., Li, T., Chen, S., Gu, Y. & Ye, S. Arthritis Rheum. 67, 3190–3200 (2015).
Dwivedi, N. et al. FASEB J. 28, 2840–2851 (2014).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Muller, S., Radic, M. Oxidation and mitochondrial origin of NET DNA in the pathogenesis of lupus. Nat Med 22, 126–127 (2016). https://doi.org/10.1038/nm.4044
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.4044
This article is cited by
-
COVID-19 infection: a possible induction factor for development of autoimmune diseases?
Immunologic Research (2023)