A new study identifies the RAS-MAPK pathway to be an Achilles' heel of EML4-ALK fusion-positive lung cancer and suggests that up-front combination therapy directed against both pathways can achieve sustained suppression of tumor growth.
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EML4-ALK fusion protein in Lung cancer cells enhances venous thrombogenicity through the pERK1/2-AP-1-tissue factor axis
Journal of Thrombosis and Thrombolysis Open Access 08 November 2023
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Zhou, B., Cox, A. Up-front polytherapy for ALK-positive lung cancer. Nat Med 21, 974–975 (2015). https://doi.org/10.1038/nm.3942
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DOI: https://doi.org/10.1038/nm.3942
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EML4-ALK fusion protein in Lung cancer cells enhances venous thrombogenicity through the pERK1/2-AP-1-tissue factor axis
Journal of Thrombosis and Thrombolysis (2023)