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Liquid biopsies reveal the dynamic nature of resistance mechanisms in solid tumors

Nature Medicine volume 21, pages 663–665 (2015)Cite this article

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Two new studies demonstrate that so-called 'liquid biopsies' may reveal important genomic information needed to monitor treatment responses, forecast tumor recurrences, and provide a rationale for novel therapeutic strategies in patients with lung cancer and colon cancer.

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Figure 1: Longitudinal monitoring of cfDNA in a patient with a solid tumor.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. Catherine B. Meador is in the Department of Cancer Biology, Vanderbilt University School of Medicine and Vanderbilt Ingram Cancer Center, Nashville, Tennessee, USA.,

    Catherine B Meador

  2. Christine M. Lovly is in the Department of Cancer Biology and the Department of Medicine, Vanderbilt University School of Medicine and Vanderbilt Ingram Cancer Center, Nashville, Tennessee, USA.,

    Christine M Lovly

Authors
  1. Catherine B Meador
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  2. Christine M Lovly
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Correspondence to Christine M Lovly.

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Competing interests

C.M.L. has served as a consultant for Pfizer, Novartis, and Sequenom and has been an invited speaker for Abbott and Qiagen. C.M.L. has received research support from AstraZeneca and Novartis.

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Meador, C., Lovly, C. Liquid biopsies reveal the dynamic nature of resistance mechanisms in solid tumors. Nat Med 21, 663–665 (2015). https://doi.org/10.1038/nm.3899

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