Type 2 diabetes occurs when the pancreatic beta cells fail to meet the increased insulin requirement in insulin-resistant individuals. A new therapeutic approach targeting glutamate receptors on beta cells improves insulin secretion and preserves beta cell mass.
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Wollheim, C., Maechler, P. Beta cell glutamate receptor antagonists: novel oral antidiabetic drugs?. Nat Med 21, 310–311 (2015). https://doi.org/10.1038/nm.3835
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DOI: https://doi.org/10.1038/nm.3835
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