Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Response to Burgess

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The effect of pyruvate cycling, expressed as VPK/VTCA, on the kinetics of hepatic [1-13C]glutamate (13C1-Glu) enrichment during a 2-h infusion of [1-13C]acetate.
Figure 2: 13C spectra acquired from human liver at baseline (gray) and after an infusion of [3-13C]lactate (black).

References

  1. Burgess, S.C. et al. Nat. Med. 21, 108–109 (2015).

    Article  CAS  Google Scholar 

  2. Befroy, D.E. et al. Nat. Med. 20, 98–102 (2014).

    Article  CAS  Google Scholar 

  3. Petersen, K.F. et al. Metabolism 44, 1380–1383 (1995).

    Article  CAS  Google Scholar 

  4. Petersen, K.F. et al. Am. J. Physiol. 267, E273–E277 (1994).

    CAS  Google Scholar 

  5. Sunny, N.E. et al. Cell Metab. 14, 804–810 (2011).

    Article  CAS  Google Scholar 

  6. Jones, J.G. et al. Am. J. Physiol. 275, E843–E852 (1998).

    CAS  Google Scholar 

  7. Jeffrey, F.M. et al. Am. J. Physiol. 271, E788–E799 (1996).

    CAS  Google Scholar 

  8. Cohen, S.M. et al. Proc. Natl. Acad. Sci. USA 78, 60–64 (1981).

    Article  CAS  Google Scholar 

  9. Rognstad, R. & Katz, J. J. Biol. Chem. 252, 1831–1833 (1977).

    CAS  Google Scholar 

  10. Krebs, H.A. et al. Adv. Enzyme Regul. 2, 71–81 (1964).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Gerald I Shulman.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Befroy, D., Kibbey, R., Perry, R. et al. Response to Burgess. Nat Med 21, 109–110 (2015). https://doi.org/10.1038/nm.3790

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm.3790

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing