A new study provides a rationale for the use of poly (ADP-ribose) polymerase (PARP) inhibitors to trigger irreparable DNA damage as a therapeutic approach in acute myeloid leukemia (AML). It also provides support for combining PARP inhibitors with agents that reduce HOXA9 protein levels.
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Wang, L., Hamard, PJ. & Nimer, S. PARP inhibitors: a treatment option for AML?. Nat Med 21, 1393–1394 (2015). https://doi.org/10.1038/nm.4007
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DOI: https://doi.org/10.1038/nm.4007
